Lambert R K
J Appl Physiol (1985). 1986 Jul;61(1):138-49. doi: 10.1152/jappl.1986.61.1.138.
The computational model for expiratory flow in humans of Lambert and associates (J. Appl. Physiol. Respirat. Environ. Exercise Physiol. 52: 44-56, 1982) was used to investigate the effect of bronchial constrictions in three airway zones on the density dependence of maximal expiratory flow. It was found that constriction of the peripheral airways (less than 2 mm diam) reduced density dependence and increased the volume of isoflow. Constriction of the larger intraparenchymal airways resulted in increased density dependence at low lung volumes and essentially normal values at other volumes. The volume of isoflow was reduced. Extraparenchymal (but intrathoracic) airway constriction caused no change in the volume of isoflow but caused increased density dependence at the higher lung volumes. It was shown that in these model simulations the addition of extraparenchymal constriction to intraparenchymal constriction causes essentially no changes in density dependence. An increased volume of isoflow and significantly decreased density dependence at 50 and 25% vital capacity were produced by simulated constrictions only in the peripheral airways.
兰伯特及其同事（《应用生理学杂志：呼吸、环境与运动生理学》第52卷：44 - 56页，1982年）建立的人体呼气流量计算模型，被用于研究三个气道区域的支气管收缩对最大呼气流量密度依赖性的影响。研究发现，外周气道（直径小于2毫米）收缩会降低密度依赖性并增加等流量容积。较大的肺实质内气道收缩会导致低肺容积时密度依赖性增加，而在其他肺容积时基本正常。等流量容积减小。肺外（但胸腔内）气道收缩对等流量容积无影响，但会导致较高肺容积时密度依赖性增加。结果表明，在这些模型模拟中，肺外收缩叠加肺实质内收缩对密度依赖性基本无影响。仅外周气道模拟收缩会导致等流量容积增加，以及在肺活量50%和25%时密度依赖性显著降低。
