Lambert R K
J Appl Physiol Respir Environ Exerc Physiol. 1984 Oct;57(4):958-70. doi: 10.1152/jappl.1984.57.4.958.
The computational model for forced expiratory flow from human lungs of Lambert and associates (J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 52: 44-56, 1982) was used to investigate the sensitivity of maximal expiratory flow to lung properties. It was found that maximal flow is very sensitive to recoil pressure and airway areas but not very sensitive to lung volume, airway compliance, and airway length. Linear programming was used to show that a given air flow-pressure curves was compatible with a fairly wide range of airway properties. Additional data for maximal flow with a He-O2 mixture narrowed the range somewhat. It was shown that the flow-pressure curve contains more information about central than peripheral airways and that information about the latter is obtainable only from flows at recoils less than 2 cmH2O. Parameter ranges compatible with individual flow-pressure curves showed differences that demonstrated that such curves give some indication of individual central airway properties.
兰伯特及其同事（《应用生理学杂志：呼吸、环境与运动生理学》52: 44 - 56, 1982）提出的人体肺部用力呼气流量计算模型，用于研究最大呼气流量对肺特性的敏感性。研究发现，最大流量对弹性回缩压和气道面积非常敏感，但对肺容积、气道顺应性和气道长度不太敏感。采用线性规划表明，给定的气流 - 压力曲线与相当广泛的气道特性范围是兼容的。使用氦 - 氧混合气时最大流量的额外数据使该范围有所缩小。结果表明，气流 - 压力曲线包含的关于中央气道的信息比外周气道更多，并且关于外周气道的信息仅可从弹性回缩小于2 cmH₂O时的流量中获取。与个体气流 - 压力曲线兼容的参数范围显示出差异，这表明此类曲线能给出一些个体中央气道特性的指示。
