Hida W, Shindoh C, Kikuchi Y, Chonan T, Inoue H, Sasaki H, Takishima T
J Appl Physiol (1985). 1986 Jul;61(1):91-7. doi: 10.1152/jappl.1986.61.1.91.
The ventilatory response to electrically induced contraction (EIC) and passive movement (PM) of hindlimb muscles at different levels of anesthesia was studied in 11 chloralose-urethan anesthetized dogs with and without rhizotomy. The level of anesthesia was assessed by corneal reflexes and measurements of the ventilatory response to hypercapnia. Muscle contraction was induced by electrically stimulating the peripheral cut ends of the sciatic and femoral nerves for 4-5 min, and PM was induced manually at the same frequency and amplitude as during EIC. In spinal intact dogs (n = 7), initial rapid increases in minute ventilation (VE) during EIC and PM were found in both light and deep anesthesia. Further increases in VE above the initial rise were seen during EIC but not PM. The initial rapid increases in VE did not differ between the two anesthetic levels. The steady-state ventilatory response during EIC decreased as anesthesia deepened but did not do so during PM. Rhizotomy (n = 4) abolished the initial rapid increase in VE during EIC and PM and the steady-state VE response to PM at both anesthetic levels. These results suggest that the transitional ventilatory response is neurally mediated from the muscles and not affected by the level of general anesthesia. Additionally, the anesthesia-induced reduction of ventilatory response may be due to depression of responsiveness to CO2 rather than to the inspiratory motoneuron pathway.
在11只使用水合氯醛-乌拉坦麻醉且有或没有进行神经根切断术的犬中，研究了在不同麻醉水平下对后肢肌肉电诱发收缩（EIC）和被动运动（PM）的通气反应。通过角膜反射和对高碳酸血症通气反应的测量来评估麻醉水平。通过电刺激坐骨神经和股神经的外周切断端4-5分钟来诱发肌肉收缩，并且以与EIC期间相同的频率和幅度手动诱发PM。在脊髓完整的犬（n = 7）中，在浅麻醉和深麻醉下，EIC和PM期间最初分钟通气量（VE）都迅速增加。在EIC期间可见VE在最初升高之上进一步增加，但在PM期间未出现。两种麻醉水平下VE的最初快速增加没有差异。EIC期间的稳态通气反应随着麻醉加深而降低，但PM期间没有。神经根切断术（n = 4）消除了EIC和PM期间VE的最初快速增加以及两种麻醉水平下对PM的稳态VE反应。这些结果表明，过渡性通气反应是由肌肉神经介导的，不受全身麻醉水平的影响。此外，麻醉引起的通气反应降低可能是由于对二氧化碳反应性的降低，而不是吸气运动神经元途径的原因。
