Weissman M L, Wasserman K, Huntsman D J, Whipp B J
J Appl Physiol Respir Environ Exerc Physiol. 1979 May;46(5):878-84. doi: 10.1152/jappl.1979.46.5.878.
To investigate the importance of the major neural afferent component from the exercising extremities in exercise hyperpnea, rhythmic contraction of hindlimb muscles was produced in the dog, by electrically stimulating the peripheral cut ends of the sciatic and femoral nerves, bilaterally, for 4- to 5-min periods. VE, VCO2, and VO2 were computed breath-by-breath and PaCO2 was monitored continuously with an indwelling arterial electrode. During exercise, VO2 and VCO2 were approximately doubled in the steady state, rising with t1/2 of 25 +/- 2 and 35 +/- 4 s, respectively. VE increased within five breaths after exercise onset, and thereafter rose to a steady state with a t1/2 of 37 +/- 5 s. Mean PaCO2 increased transiently within the 1st min of stimulation but was not significantly different from control in the steady state. We conclude that the major neural afferent component from the contracting muscles is not an obligatory requirement for normal ventilatory response in the steady state of phasic exercise.
为研究运动肢体的主要神经传入成分在运动性通气过度中的重要性，通过双侧电刺激坐骨神经和股神经的外周切断端4至5分钟，使犬后肢肌肉产生节律性收缩。逐次呼吸计算每分通气量（VE）、二氧化碳排出量（VCO2）和耗氧量（VO2），并使用留置动脉电极连续监测动脉血二氧化碳分压（PaCO2）。运动期间，稳态时VO2和VCO2分别增加约一倍，其半衰期分别为25±2秒和35±4秒。运动开始后5次呼吸内VE增加，此后升至稳态，半衰期为37±5秒。刺激第1分钟内平均PaCO2短暂升高，但稳态时与对照组无显著差异。我们得出结论，在相性运动的稳态中，收缩肌肉的主要神经传入成分并非正常通气反应的必要条件。
