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SOX10。

SOX10.

机构信息

Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA

出版信息

J Clin Pathol. 2023 Oct;76(10):649-653. doi: 10.1136/jcp-2023-208924. Epub 2023 Jun 19.

Abstract

The SOX gene encodes for transcription factors that are involved in embryogenesis and cell differentiation. Specifically, aids with neural crest shuttling and development. In diagnostic histopathology, Sox10 immunostain is a helpful ancillary test due to its high sensitivity for melanocytic and peripheral nerve sheath neoplasms, and its role in distinguishing triple-negative breast carcinomas from gynaecological carcinoma, cutaneous adnexal neoplasms and salivary glands neoplasms from histological mimics.

摘要

SOX 基因编码参与胚胎发生和细胞分化的转录因子。具体来说,它有助于神经嵴穿梭和发育。在诊断组织病理学中,Sox10 免疫染色是一种有用的辅助检测方法,因为它对黑色素细胞和周围神经鞘肿瘤具有很高的敏感性,并且在鉴别三阴性乳腺癌与妇科癌、皮肤附属器肿瘤和唾液腺肿瘤与组织学模拟物方面具有重要作用。

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