Koskinen E V, Salenius P, Alho A
Acta Orthop Scand. 1979 Apr;50(2):129-38. doi: 10.3109/17453677908989747.
A massive allografting of deep-frozen cadaver bone or hemi-joint was performed in 11 patients with tumours which were diagnosed as aggressive, low-grade malignancies. One patient died from a pre-existing hepatic insufficiency. The other 10 patients have been followed up from 1 to 8 years. These patients received two bone grafts and eight hemi-joint grafts around the knee joint. The operative procedure consisted of fixation of the graft by stable osteosynthesis, surrounding the graft-host junction with an autogeneic iliac chips cuff and, in cases of hemi-joint grafts, reconstruction of the ligaments. X-ray, scintigraphy and biopsy were used to judge the incorporation of the graft. The patients had to be prepared to face a considerable morbidity with long non-weight-bearing periods and possibly further operations. A full restitution of function was achieved in the bone graft cases. The patients with hemi-joint grafts were also able to retain their limb with a good or satisfactory function. No metastases or recurrences were experienced. The allograft procedure appears to be useful for younger adults, whose long life expectancy makes this operation justifiable, although the fate of cartilage still is unpredictable.
对11例被诊断为侵袭性低度恶性肿瘤的患者进行了深冻尸体骨或半关节的大规模同种异体移植。1例患者死于术前存在的肝功能不全。其他10例患者进行了1至8年的随访。这些患者在膝关节周围接受了2次骨移植和8次半关节移植。手术过程包括通过稳定的骨合成固定移植物，用自体髂骨碎骨袖套围绕移植物-宿主连接处，对于半关节移植，还包括韧带重建。通过X线、闪烁扫描和活检来判断移植物的融合情况。患者必须做好面对相当高发病率、长时间不负重以及可能需要进一步手术的准备。骨移植病例实现了功能的完全恢复。半关节移植的患者也能够保留肢体，功能良好或令人满意。未出现转移或复发情况。同种异体移植手术似乎对年轻成年人有用，他们较长的预期寿命使得这种手术合理，尽管软骨的命运仍然不可预测。
