Di Vincenzo Olivia, D'Elia Lanfranco, Ballarin Giada, Pasanisi Fabrizio, Scalfi Luca
Department of Public Health, School of Medicine, Federico II University, Via Sergio Pansini 5, 80131, Naples, Italy.
Department of Clinical Medicine and Surgery School of Medicine, Federico II University, Via Sergio Pansini 5, 80131, Naples, Italy.
Nutr Metab Cardiovasc Dis. 2023 Aug;33(8):1501-1510. doi: 10.1016/j.numecd.2023.05.012. Epub 2023 May 12.
The Controlling Nutritional Status (CONUT) score is a tool for assessing the risk of malnutrition (undernutrition) that can be calculated from albumin concentration, total peripheral lymphocyte count, and total cholesterol concentration. CONUT score has been proposed as a promising prognostic marker in several clinical settings; however, a consensus on its prognostic value in patients with stroke is lacking. The aim of this systematic review and meta-analysis was to evaluate the relationship between CONUT score and clinical outcomes in patients with stroke based on all current available studies.
Systematic research on PubMed, Scopus and Web of Science from inception to February 2023 was performed on the association between CONUT score and clinical outcomes in patients with stroke. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses were followed. Methodological quality was evaluated using the Newcastle-Ottawa Scale quality assessment tool. Pooled effect estimation was calculated by a random-effect model. Through the initial literature search, 15 studies (all high-quality) including 16 929 patients were found to be eligible and analysed in the meta-analysis. A significant risk of malnutrition (in most studies defined by a CONUT score ≥5) was directly associated with mortality, higher risk of poor functional outcome according to the modified Rankin Scale and total infection development. Evidence was consistent for acute ischaemic stroke and preliminary for acute haemorrhagic stroke.
CONUT score is an independent prognostic indicator, and it is associated with major disability and infection development during hospitalisation.
CRD42022306560.
控制营养状况（CONUT）评分是一种用于评估营养不良（营养不足）风险的工具，可根据白蛋白浓度、外周血淋巴细胞总数和总胆固醇浓度计算得出。CONUT评分已被提议作为几种临床环境中有前景的预后标志物；然而，对于其在中风患者中的预后价值尚无共识。本系统评价和荟萃分析的目的是基于所有现有研究评估CONUT评分与中风患者临床结局之间的关系。
对PubMed、Scopus和Web of Science从创刊至2023年2月进行了关于CONUT评分与中风患者临床结局之间关联的系统研究。遵循系统评价和荟萃分析的首选报告项目。使用纽卡斯尔-渥太华量表质量评估工具评估方法学质量。采用随机效应模型计算合并效应估计值。通过初步文献检索，发现15项研究（均为高质量），包括16929例患者符合纳入标准并进行荟萃分析。营养不良的显著风险（在大多数研究中定义为CONUT评分≥5）与死亡率、根据改良Rankin量表得出的功能结局不良风险增加以及总感染发生率直接相关。证据在急性缺血性中风中是一致的，在急性出血性中风中是初步的。
CONUT评分是一个独立的预后指标，并且与住院期间的严重残疾和感染发生相关。
PROSPERO注册号：CRD42022306560。
