Sequeira Jaison Jeevan, Nizamuddin Sheikh, van Driem George, Mustak Mohammed S
Department of Applied Zoology, Mangalore University, Mangalagangotri, Mangaluru, 574199, India.
German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Genes Genomics. 2023 Nov;45(11):1409-1422. doi: 10.1007/s13258-023-01409-2. Epub 2023 Jun 19.
The TAS2R38 gene carries markers for phenylthiocarbamide (PTC) sensitivity. Various studies have investigated the genotype-phenotype association pattern for bitter tasting ability and other factors in different populations. However, a paucity of such information for endogamous Indian populations is the reason behind this study.
To study the association of phenylthiocarbamide (PTC) sensitivity with TAS2R38 gene variations in Koṅkaṇī Sārasvata Brahmin population.
We studied the association of the alleles rs714598, rs1726866, rs10246939 with PTC sensitivity and other factors in the Koṅkaṇī Sārasvata Brahmin population. DNA was extracted from 114 individuals belonging to the Koṅkaṇī Sārasvata Brahmin community. The TAS2R38 gene was sequenced to find the genotype distribution pattern. The association between genotype and phenotype was checked using the Chi-Square test and multifactorial logistical regression.
We observed a 58.8% frequency of the AVI haplotype, which is the most prevalent in European populations. A higher number of non-taster haplotypes and diplotypes were observed in Koṅkaṇī Sārasvata Brahmins, with the allele rs10246939 showing a significant association with PTC bitter taste sensitivity in both allelic (p = 8.6 × 10; Allele-G, OR = 3.57 [95% CI = 1.66-7.69]) and genotype-based (p = 6.9 × 10; genotype-AG, OR = 3.11 [95% CI = 0.73-13.20]; genotype-GG, OR = 40 [95% CI = 3.58-447.03]) tests.
Our results are in line with earlier studies, which report an association between PTC sensitivity and the TAS2R38 gene in different populations. In the global context, Koṅkaṇī Sārasvata Brahmins, who are mostly distributed along the southwestern coast of India, show a PTC sensitivity pattern slightly similar to that of West Eurasian populations. Our findings suggest ancestry specific selection in TAS2R38 gene variations for taste sensitivity at global level.
TAS2R38基因携带苯硫脲（PTC）敏感性的标记。各种研究调查了不同人群中苦味品尝能力及其他因素的基因型-表型关联模式。然而，印度内婚制人群中此类信息匮乏是本研究的背后原因。
研究科纳尼·萨拉斯瓦塔婆罗门人群中苯硫脲（PTC）敏感性与TAS2R38基因变异的关联。
我们研究了科纳尼·萨拉斯瓦塔婆罗门人群中rs714598、rs1726866、rs10246939等位基因与PTC敏感性及其他因素的关联。从114名属于科纳尼·萨拉斯瓦塔婆罗门社区的个体中提取DNA。对TAS2R38基因进行测序以发现基因型分布模式。使用卡方检验和多因素逻辑回归检查基因型与表型之间的关联。
我们观察到AVI单倍型的频率为58.8%，这在欧洲人群中最为普遍。在科纳尼·萨拉斯瓦塔婆罗门中观察到更多的非品尝者单倍型和双倍型，等位基因rs10246939在等位基因（p = 8.6×10；等位基因-G，OR = 3.57 [95% CI = 1.66 - 7.69]）和基于基因型（p = 6.9×10；基因型-AG，OR = 3.11 [95% CI = 0.73 - 13.20]；基因型-GG，OR = 40 [95% CI = 3.58 - 447.03]）的测试中均显示与PTC苦味敏感性有显著关联。
我们的结果与早期研究一致，早期研究报告了不同人群中PTC敏感性与TAS2R38基因之间的关联。在全球范围内，主要分布在印度西南海岸的科纳尼·萨拉斯瓦塔婆罗门表现出与西欧亚人群略有相似的PTC敏感性模式。我们的研究结果表明在全球水平上TAS2R38基因变异中存在特定祖先的味觉敏感性选择。
