Department of Food Science and Nutrition, Keimyung University, 1095 Dalgubeol-daero, Dalseo-Gu, Daegu 42601, Korea.
Nutrients. 2019 Aug 21;11(9):1973. doi: 10.3390/nu11091973.
Bitterness-sensing protein taste receptor type-2 member 38 (, T2R38) mediates taste perception and various physiological responses, including energy- and adiposity-related mechanisms. This study examined whether the genetic variant rs10246939 C > T in was associated with food intake and body size as well as obesity risk. Data from the Korean Multi-Rural Communities Cohort study (1338 males and 2229 females) were analyzed to obtain the intake of six food groups, alcohol consumption, smoking status and anthropometric measurements, including height, weight, waist and hip circumference, and body mass index (BMI), according to the rs10246939 genotype. Findings suggested that females with the TT genotype consumed more fruit (adjusted = 0.025) and had significantly higher body weights (adjusted = 0.046) and BMIs (adjusted = 0.003) than individuals with other genotypes. Having the TT genotype also increased the risk of obesity by 1.75-fold (95% confidence interval: 1.31-2.36) in females. The genetic variation had a minimal influence on the males' dietary intake, but tended to increase the adiposity risk. In conclusion, rs10246939 variation was associated with Koreans' dietary intake and increased their risk of obesity. Although more detailed statistical analyses in the larger cohort are required, current study suggested that, as a genetic predictive marker, bitterness receptor variations may have a large implication in obesity prevention and treatment.
苦味感知蛋白味觉受体型 2 成员 38（T2R38）介导味觉感知和各种生理反应，包括与能量和肥胖相关的机制。本研究旨在探讨 基因中的 rs10246939C>T 遗传变异是否与食物摄入和体型以及肥胖风险相关。本研究对韩国多农村社区队列研究（1338 名男性和 2229 名女性）的数据进行了分析，根据 rs10246939 基因型，获得了六类食物的摄入量、酒精摄入量、吸烟状况和人体测量学指标，包括身高、体重、腰围和臀围以及体重指数（BMI）。结果表明，TT 基因型的女性摄入更多的水果（调整后 P=0.025），体重（调整后 P=0.046）和 BMI（调整后 P=0.003）明显更高。TT 基因型的女性肥胖风险增加 1.75 倍（95%置信区间：1.31-2.36）。遗传变异对男性的饮食摄入影响较小，但有增加肥胖风险的趋势。总之， rs10246939 变异与韩国人的饮食摄入有关，并增加了他们肥胖的风险。虽然需要在更大的队列中进行更详细的统计分析，但目前的研究表明，作为一种遗传预测标志物，苦味受体的变异可能对肥胖的预防和治疗具有重要意义。
