Neurobehavioural Dynamics Laboratory, Department of Health Sciences and Technology, ETH Zurich, Schwerzenbach, Switzerland.
Nat Neurosci. 2023 Jul;26(7):1160-1164. doi: 10.1038/s41593-023-01365-w. Epub 2023 Jun 19.
Brain orexin (hypocretin) neurons are implicated in sleep-wake switching and reward-seeking but their roles in rapid arousal dynamics and reward perception are unclear. Here, cell-specific stimulation, deletion and in vivo recordings revealed strong correlative and causal links between pupil dilation-a quantitative arousal marker-and orexin cell activity. Coding of arousal and reward was distributed across orexin cells, indicating that they specialize in rapid, multiplexed communication of momentary arousal and reward states.
脑源性食欲素（下丘脑分泌素）神经元与睡眠-觉醒转换和寻求奖赏有关，但它们在快速觉醒动态和奖赏感知中的作用尚不清楚。在这里，细胞特异性刺激、缺失和体内记录显示，瞳孔扩张——一种定量的觉醒标志物——与食欲素细胞活动之间存在很强的相关和因果关系。觉醒和奖赏的编码分布在食欲素细胞中，表明它们专门用于快速、多路复用地传递瞬间的觉醒和奖赏状态。
