Clinical and Experimental Psychopathology Laboratory, University Hospital Geneva, Belle-Idée, Bâtiment Les Voirons, Chemin Petit-Bel-Air 2, 1226, Thônex, Switzerland.
Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, Zurich, Switzerland.
Sci Rep. 2023 Jun 19;13(1):9953. doi: 10.1038/s41598-023-37103-2.
A growing body of research has placed the ventral striatum at the center of a network of cerebral regions involved in anticipating rewards in healthy controls. However, little is known about the functional connectivity of the ventral striatum associated with reward anticipation in healthy controls. In addition, few studies have investigated reward anticipation in healthy humans with different levels of schizotypy. Here, we investigated reward anticipation in eighty-four healthy individuals (44 females) recruited based on their schizotypy scores. Participants performed a variant of the Monetary Incentive Delay Task while undergoing event-related fMRI.Participants showed the expected decrease in response times for highly rewarded trials compared to non-rewarded trials. Whole-brain activation analyses replicated previous results, including activity in the ventral and dorsal striatum. Whole-brain psycho-physiological interaction analyses of the left and right ventral striatum revealed increased connectivity during reward anticipation with widespread regions in frontal, parietal and occipital cortex as well as the cerebellum and midbrain. Finally, we found no association between schizotypal personality severity and neural activity and cortico-striatal functional connectivity. In line with the motivational, attentional, and motor functions of rewards, our data reveal multifaceted cortico-striatal networks taking part in reward anticipation in healthy individuals. The ventral striatum is connected to regions of the salience, attentional, motor and visual networks during reward anticipation and thereby in a position to orchestrate optimal goal-directed behavior.
越来越多的研究将腹侧纹状体置于参与健康对照者预期奖励的大脑区域网络的中心。然而，对于与健康对照者预期奖励相关的腹侧纹状体的功能连接知之甚少。此外，很少有研究调查具有不同精神分裂症倾向水平的健康人类对奖励的预期。在这里，我们根据精神分裂症倾向评分招募了 84 名健康个体（44 名女性），研究了他们的奖励预期。参与者在进行事件相关 fMRI 时执行了金钱奖励延迟任务的变体。参与者在高度奖励的试验中表现出比非奖励试验预期的反应时间减少。全脑激活分析复制了先前的结果，包括腹侧和背侧纹状体的活动。左右腹侧纹状体的全脑心理生理相互作用分析显示，在奖励预期期间，与额叶、顶叶和枕叶皮层以及小脑和中脑广泛区域的连接增加。最后，我们没有发现精神分裂症人格严重程度与神经活动和皮质纹状体功能连接之间存在关联。与奖励的动机、注意力和运动功能一致，我们的数据揭示了健康个体在奖励预期中参与的多方面皮质纹状体网络。腹侧纹状体在奖励预期期间与突显、注意力、运动和视觉网络的区域相连，从而能够协调最佳的目标导向行为。
