评估公众对直接面向消费者（DTC）基因检测的看法以及他们对 DTC 网站免责声明信息的解读。
Assessing the general public's view of direct-to-consumer (DTC) genetic testing and their interpretation of DTC website disclaimer messages.
机构信息
Division of Human Genetics, Ohio State University Wexner Medical Center, Columbus, OH, 43420, USA.
Ohio Health Cancer Genetic Counseling, Bing Cancer Center, Columbus, OH, 43214, USA.
出版信息
Eur J Hum Genet. 2023 Aug;31(8):939-944. doi: 10.1038/s41431-023-01411-y. Epub 2023 Jun 19.
The general public continues to show increased interest and uptake of Direct-to-Consumer (DTC) genetic testing. We conducted an online survey (N = 405) to assess genetics knowledge, interest, and outcome expectancy of DTC genetic testing before and after exposure to a sample DTC disclaimer message. Descriptive statistics were used to analyze the relationship between previous genetic knowledge, attitudes and self-reported systematic processing of a sample DTC disclaimer message, outcome expectancies, and interest to pursue DTC genetic testing. Increased genetic knowledge and more positive attitudes towards DTC genetic testing were associated with increased self-reported systematic processing of the DTC disclaimer message. Further, self-reported systematic processing of the DTC disclaimer message was associated with greater interest in pursuing DTC genetic testing but did not predict outcome expectancies. As DTC genetic testing continues to gain in popularity and usage, additional research is imperative to better understand participants' motivations and processing of the DTC disclaimer messages to improve the user experience.
公众对直接面向消费者（DTC）基因检测的兴趣和接受度持续增加。我们进行了一项在线调查（N=405），在接触 DTC 免责声明示例后，评估了 DTC 基因检测的遗传知识、兴趣和结果预期。描述性统计用于分析先前的遗传知识、态度以及对 DTC 免责声明示例的自我报告系统处理之间的关系，结果预期和进行 DTC 基因检测的兴趣。遗传知识的增加和对 DTC 基因检测的更积极态度与对 DTC 免责声明消息的自我报告系统处理的增加有关。此外，对 DTC 免责声明消息的自我报告系统处理与对进行 DTC 基因检测的更大兴趣相关，但不预测结果预期。随着 DTC 基因检测的普及和使用不断增加，需要开展更多的研究，以更好地了解参与者对 DTC 免责声明消息的动机和处理方式，从而改善用户体验。
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