Department of Thoracic Surgery, Ege University School of Medicine, İzmir, Turkey.
Department of Thoracic Surgery, Health Sciences University İzmir Tepecik Education and Research Hospital, İzmir, Turkey.
World J Surg Oncol. 2023 Jun 19;21(1):183. doi: 10.1186/s12957-023-03073-y.
In this study, the effect of postoperative early nutritional supplementation on the course of the disease was investigated in patients who were operated for non-small cell lung cancer and received adjuvant chemotherapy.
The study examined the data of patients who anatomical pulmonary resection for non-small cell lung cancer and who were treated with adjuvant chemotherapy at our clinic between January 2014 and January 2020. Patients who received early postoperative nutritional supplements and those who continued with a normal diet were compared in terms of complications, mortality, recurrence, and survival.
The study sample consisted of 68 (84%) male and 13 (16%) female patients, and the mean duration of postoperative follow-up was 31.6 ± 17.9 (4-75) months. Metastasis was identified in eight (17.4%) patients in Grup compared to 10 (28.6%) patients in Group (p = 0.231). Of the total, 11 (23.9%) patients died in Group compared to 13 (37.1%) in Group (p = 0.196). Mean survival was 58.9 ± 3.8 (95% CI: 4.0-75.0) months in Group compared to 43.5 ± 4.6 (95% CI: 6.0-66.0) months in Group (p = 0.045).
Early nutritional supplements should be considered as having a positive effect especially on survival in this specific patient group involving factors with high catabolic effects, such as neoplasia, operation, and chemotherapy together.
本研究旨在探讨非小细胞肺癌术后早期营养补充对辅助化疗患者疾病进程的影响。
研究纳入了 2014 年 1 月至 2020 年 1 月在我院接受解剖性肺切除术和辅助化疗的非小细胞肺癌患者。比较了接受术后早期营养补充和继续正常饮食的患者的并发症、死亡率、复发和生存情况。
研究样本包括 68 例（84%）男性和 13 例（16%）女性患者，术后随访平均时间为 31.6±17.9（4-75）个月。Grup 组有 8 例（17.4%）患者发生转移，而 Group 组有 10 例（28.6%）患者发生转移（p=0.231）。Grup 组共有 11 例（23.9%）患者死亡，而 Group 组共有 13 例（37.1%）患者死亡（p=0.196）。Grup 组的平均生存时间为 58.9±3.8（95%CI：4.0-75.0）个月，而 Group 组的平均生存时间为 43.5±4.6（95%CI：6.0-66.0）个月（p=0.045）。
在涉及肿瘤、手术和化疗等高分解代谢因素的特定患者群体中，早期营养补充可能对生存具有积极影响。
