Sharma Avi, Daigavane Sachin, Bhake Arvind
Ophthalmology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2023 May 19;15(5):e39219. doi: 10.7759/cureus.39219. eCollection 2023 May.
Ocular surface squamous neoplasia (OSSN) is a spectrum of intraepithelial and invasive neoplastic lesions of the conjunctiva and cornea. OSSN is a rare but potentially sight-threatening ocular malignancy that can be challenging to diagnose due to its clinical and histopathological resemblance to benign ocular surface lesions. However, OSSN can lead to significant ocular and systemic morbidity, including vision loss and metastasis. Various risk factors have been identified, including ultraviolet radiation exposure, human papillomavirus infection, and immunosuppression. The histopathological analysis of the lesion is of utmost importance in diagnosing and further managing squamous cell carcinoma. The acantholytic variant of squamous cell carcinoma is uncommon. Here, we present the case of a 69-year-old male who presented with an invasive mass of progressive growth on the left eyeball extending into the visual axis. The patient underwent extended enucleation, and a histopathological analysis demonstrated a rare acantholytic variant of squamous cell carcinoma.
眼表鳞状上皮肿瘤（OSSN）是结膜和角膜的一系列上皮内及浸润性肿瘤性病变。OSSN是一种罕见但可能威胁视力的眼部恶性肿瘤，由于其在临床和组织病理学上与良性眼表病变相似，诊断具有挑战性。然而，OSSN可导致严重的眼部和全身疾病，包括视力丧失和转移。已确定多种危险因素，包括紫外线暴露、人乳头瘤病毒感染和免疫抑制。病变的组织病理学分析对鳞状细胞癌的诊断和进一步治疗至关重要。鳞状细胞癌的棘层松解变体并不常见。在此，我们报告一例69岁男性患者，其左眼出现渐进性生长的浸润性肿块并延伸至视轴。患者接受了扩大眼球摘除术，组织病理学分析显示为罕见的鳞状细胞癌棘层松解变体。
