Kim Jo-Eun, Lee Chena, Oh Kyu-Young, Huh Kyung-Hoe
Department of Oral and Maxillofacial Radiology, Seoul National University Dental Hospital.
Department of Oral and Maxillofacial Radiology, Yonsei University College of Dentistry.
Medicine (Baltimore). 2020 Aug 7;99(32):e21631. doi: 10.1097/MD.0000000000021631.
Acantholytic squamous cell carcinoma (ASCC) is an uncommon histopathologic variant of squamous cell carcinoma (SCC), which is the most common malignancy of the oral cavity. Though ASCC showed poor prognosis, the exact diagnosis is challenging.
A 59-year-old female patient with 1-month long symptoms of pain and burning sensation in the right maxilla.
Incisional biopsy in the maxilla established the pathologic diagnosis of SCC.
The patient underwent mass resection with near total maxillectomy.
The final diagnosis through the microscopic examination was ASCC. Palliative chemotherapy was done to relive the symptoms after the recurrence, however, the patient died of the disease at 8 months after her initial presentation.
Special attention should be paid to this variant of SCC because most patients with ASCC have a very poor prognosis.
棘层松解性鳞状细胞癌（ASCC）是鳞状细胞癌（SCC）一种不常见的组织病理学变异类型，而SCC是口腔最常见的恶性肿瘤。尽管ASCC预后较差，但准确诊断具有挑战性。
一名59岁女性患者，右上颌出现疼痛和烧灼感症状达1个月。
上颌切开活检确诊为SCC。
患者接受了肿块切除及近全上颌骨切除术。
经显微镜检查最终诊断为ASCC。复发后进行了姑息化疗以缓解症状，但患者在首次就诊8个月后死于该疾病。
应特别关注这种SCC变异类型，因为大多数ASCC患者预后极差。
