Research and Development Department, Sina Medical Biochemistry Technologies Co. Ltd., Shiraz 7178795844, Iran.
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.
Nanoscale. 2023 Jul 6;15(26):10882-10903. doi: 10.1039/d3nr00425b.
As an efficient class of hydrogel-based therapeutic drug delivery systems, deoxyribonucleic acid (DNA) hydrogels (particularly DNA nanogels) have attracted massive attention in the last five years. The main contributor to this is the programmability of these 3-dimensional (3D) scaffolds that creates fundamental effects, especially in treating cancer diseases. Like other active biological ingredients (ABIs), DNA hydrogels can be functionalized with other active agents that play a role in targeting drug delivery and modifying the half-life of the therapeutic cargoes in the body's internal environment. Considering the brilliant advantages of DNA hydrogels, in this survey, we intend to submit an informative collection of feasible methods for the design and preparation of DNA hydrogels and nanogels, and the responsivity of the immune system to these therapeutic cargoes. Moreover, the interactions of DNA hydrogels with cancer biomarkers are discussed in this account. Theragnostic DNA nanogels as an advanced species for both detection and therapeutic purposes are also briefly reviewed.
作为一类高效的水凝胶基治疗药物输送系统，脱氧核糖核酸（DNA）水凝胶（特别是 DNA 纳米凝胶）在过去五年中引起了广泛关注。这主要归因于这些 3 维（3D）支架的可编程性，这些支架产生了基本效应，特别是在治疗癌症疾病方面。与其他活性生物成分（ABIs）一样，DNA 水凝胶可以与其他活性剂结合，这些活性剂在靶向药物输送和修饰治疗货物在体内内环境中的半衰期方面发挥作用。考虑到 DNA 水凝胶的出色优势，在本综述中，我们旨在提交一份关于 DNA 水凝胶和纳米凝胶的设计和制备以及免疫系统对这些治疗货物的反应性的可行方法的信息集合。此外，还讨论了 DNA 水凝胶与癌症生物标志物的相互作用。治疗性 DNA 纳米凝胶作为用于检测和治疗目的的一种先进物质也被简要回顾。
