Laboratory of Medical Biology and Genetics, Department of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Department of Pulmonology, I.M. Sechenov First Moscow State Medical University, Moscow 119992, Russia.
Cells. 2024 May 24;13(11):908. doi: 10.3390/cells13110908.
The future of drug delivery offers immense potential for the creation of nanoplatforms based on nanogels. Nanogels present a significant possibility for pharmaceutical advancements because of their excellent stability and effective drug-loading capability for both hydrophobic and hydrophilic agents. As multifunctional systems, composite nanogels demonstrate the capacity to carry genes, drugs, and diagnostic agents while offering a perfect platform for theranostic multimodal applications. Nanogels can achieve diverse responsiveness and enable the stimuli-responsive release of chemo-/immunotherapy drugs and thus reprogramming cells within the TME in order to inhibit tumor proliferation, progression, and metastasis. In order to achieve active targeting and boost drug accumulation at target sites, particular ligands can be added to nanogels to improve the therapeutic outcomes and enhance the precision of cancer therapy. Modern "immune-specific" nanogels also have extra sophisticated tumor tissue-editing properties. Consequently, the introduction of a multifunctional nanogel-based drug delivery system improves the targeted distribution of immunotherapy drugs and combinational therapeutic treatments, thereby increasing the effectiveness of tumor therapy.
药物输送的未来为基于纳米凝胶的纳米平台的创造提供了巨大的潜力。由于其出色的稳定性和对亲水性和疏水性药物的有效载药能力，纳米凝胶为药物研发带来了重大的可能性。作为多功能系统，复合纳米凝胶能够携带基因、药物和诊断剂，同时为治疗学多模式应用提供了完美的平台。纳米凝胶可以实现多种响应性，并能够实现化学/免疫治疗药物的刺激响应性释放，从而重新编程 TME 中的细胞，以抑制肿瘤的增殖、进展和转移。为了实现主动靶向并增加药物在靶部位的积累，可以向纳米凝胶中添加特定的配体，以改善治疗效果并提高癌症治疗的精度。现代的“免疫特异性”纳米凝胶还具有额外复杂的肿瘤组织编辑特性。因此，引入基于多功能纳米凝胶的药物输送系统可改善免疫治疗药物的靶向分布和联合治疗，从而提高肿瘤治疗的效果。
