TH 基因启动子区域变异 C-824T 调节可卡因的主观效应。
Promoter region variant C-824T in the TH gene modulates the subjective effects of cocaine.
机构信息
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA.
Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.
出版信息
Am J Addict. 2023 Sep;32(5):506-509. doi: 10.1111/ajad.13444. Epub 2023 Jun 20.
BACKGROUND AND OBJECTIVES
This study examined how a promoter variant of TH (rs10770141) affects subjective effects of cocaine in 65 nontreatment-seeking individuals with cocaine dependence.
METHODS
Participants received cocaine/saline intravenously, and TH genotypes were evaluated.
RESULTS
Homozygous individuals for the minor T allele reported greater "good" and "bad" subjective effects to cocaine than those with the major C allele.
DISCUSSION AND CONCLUSIONS
TH rs10770141 modulates subjective effects of cocaine in participants with cocaine dependence.
SCIENTIFIC SIGNIFICANCE
These results are among the first to indicate that homozygosity of the T allele of rs10770141 modulates greater sensitivity to cocaine.
背景和目的
本研究旨在探讨促甲状腺激素（TH）的 rs10770141 启动子变异如何影响 65 名未经治疗的可卡因依赖者对可卡因的主观感受。
方法
参与者接受可卡因/生理盐水静脉注射，并评估 TH 基因型。
结果
与主要 C 等位基因相比，纯合子个体报告了更多的可卡因“良好”和“不良”主观感受。
讨论和结论
TH rs10770141 调节可卡因依赖者对可卡因的主观感受。
科学意义
这些结果是首批表明 rs10770141 的 T 等位基因纯合性调节对可卡因更高敏感性的结果之一。
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