State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
Org Biomol Chem. 2023 Jul 5;21(26):5451-5456. doi: 10.1039/d3ob00780d.
, also known as "Qinghao" in Chinese, is a famous traditional Chinese medicine and has been used for the treatment of malaria and various tumors. In this study, three novel sesquiterpenoid-flavonol hybrids, artemannuols A-C (1-3), were isolated and elucidated by extensive spectral data and ECD calculations. Structurally, artemannuols A-C (1-3) are the first examples of sesquiterpenoid-flavonol hybrids fused by an ether bond, among which artemannuols A and B (1 and 2) are composed of bisabolane-type sesquiterpenoid and flavonol moieties, and artemannuol C (3) is composed of humulane-type sesquiterpenoid and flavonol moieties. The antihepatoma assay suggested that compounds 1-3 showed inhibitory effects against HepG2, Huh7, and SK-Hep-1 cell lines with IC values in the range of 32.7 to 70.4 μM.
青蒿，又名“qinghao”，是一种著名的中药，用于治疗疟疾和各种肿瘤。在这项研究中，通过广泛的光谱数据和 ECD 计算，分离并阐明了三种新型倍半萜-黄酮醇杂合体，即 artemannuols A-C（1-3）。在结构上，artemannuols A-C（1-3）是通过醚键融合的倍半萜-黄酮醇杂合体的第一个例子，其中 artemannuols A 和 B（1 和 2）由双氢青蒿素型倍半萜和黄酮醇部分组成，而 artemannuol C（3）由葎草酮型倍半萜和黄酮醇部分组成。抗肝癌实验表明，化合物 1-3 对 HepG2、Huh7 和 SK-Hep-1 细胞系表现出抑制作用，IC 值在 32.7 到 70.4 μM 范围内。
