青蒿素 A-F，青蒿中首次发现的由 6'-O-克罗尼定-β-吡喃葡萄糖苷取代的天然倍半萜类化合物。
Artemeriosides A-F, the first examples of natural sesquiterpenoids substituted by a 6'-O-crontonyl β-glucopyranoside from Artemisia annua.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.
出版信息
Fitoterapia. 2023 Sep;169:105619. doi: 10.1016/j.fitote.2023.105619. Epub 2023 Jul 22.
Artemeriosides A-F (1-6), six novel sesquiterpenoids containing a 6'-O-crontonyl β-glucopyranoside, were isolated from Artemisia annua L. Their structures were determined by spectral data including HRESIMS, IR, UV, 1D and 2D NMR, and ECD calculations. Compounds 1-6 represented the first examples of natural sesquiterpenoid substituted by 6'-O-crontonyl β-glucopyranoside. By antihepatoma assay, compounds 1 and 2 demonstrated inhibitory effect against both HepG2 and SK-Hep-1 cells with inhibitory ratios of 77.0%, 88.8%, and 86.8%, 83.9% at 200.0 μM, and compound 1 showed inhibitory activity against Huh7 cells with inhibitory ratio of 56.8%.
青蒿素 A-F（1-6），六种新型倍半萜类化合物，含有 6'-O-克罗诺尼基-β-吡喃葡萄糖苷，从青蒿中分离得到。它们的结构通过包括 HRESIMS、IR、UV、1D 和 2D NMR 以及 ECD 计算在内的光谱数据确定。化合物 1-6 代表了天然倍半萜类化合物被 6'-O-克罗诺尼基-β-吡喃葡萄糖苷取代的第一个例子。通过抗肝癌测定，化合物 1 和 2 在 200.0 μM 时对 HepG2 和 SK-Hep-1 细胞均显示出抑制作用，抑制率分别为 77.0%、88.8%和 86.8%、83.9%，化合物 1 对 Huh7 细胞显示出抑制活性，抑制率为 56.8%。
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