School of Chemical Science and Engineering, Advanced Research Institute, Tongji University, 1239 Siping Road, Shanghai 200092, P. R. China.
School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
Chem Soc Rev. 2023 Jul 3;52(13):4443-4487. doi: 10.1039/d2cs00476c.
Supramolecular chirality is involved not only in biological events such as gene communication, replication, and enzyme catalysis but also in artificial self-assembly systems and aggregated materials. The precise control of supramolecular chirality, and especially supramolecular chirality inversion (SMCI), would deepen the understanding of chiral transfer and regulation in both living systems and artificial self-assembly systems, providing efficient ways to construct advanced chiral materials with an optimum assembly pathway necessary for various functions. In this review, the fundamental principles of SMCI are comprehensively summarized, with a focus on the helical assemblies having opposite handedness or chiroptical properties of the compositions. Thereafter, various SMCI strategies that have been developed for chiral nanostructures and assembled materials are systematically reviewed, and the promising applications of SMCI, including chiroptical switches, chiral recognition, enantiomeric separation, asymmetric catalysis, chiral optoelectronic materials, chiral spin filters, and biomedical uses, are highlighted accordingly. Finally, the scientific challenges and future perspectives for assembling materials with SMCI are also discussed.
超分子手性不仅涉及基因通讯、复制和酶催化等生物事件，还涉及人工自组装体系和聚集材料。超分子手性的精确控制，特别是超分子手性反转（SMCI），将加深对生命系统和人工自组装体系中手性传递和调控的理解，为构建具有各种功能所需的最佳组装途径的先进手性材料提供有效的方法。在这篇综述中，全面总结了 SMCI 的基本原理，重点介绍了具有相反手性或组成物的手性光学性质的螺旋组装体。此后，系统地综述了用于手性纳米结构和组装材料的各种 SMCI 策略，并突出了 SMCI 的有前景的应用，包括手性光开关、手性识别、对映体分离、不对称催化、手性光电材料、手性自旋滤波器和生物医学用途。最后，还讨论了利用 SMCI 组装材料的科学挑战和未来展望。
