铜/硒比值与对 SARS-CoV-2 感染免疫反应的关系。
Association between the copper/selenium ratio and the immune response to SARS-CoV-2 infection.
机构信息
Department of Laboratory Sciences, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, 7718175911, Iran.
Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, 7718175911, Iran.
出版信息
Biomark Med. 2023 Mar;17(6):307-317. doi: 10.2217/bmm-2022-0530. Epub 2023 Jun 20.
To assess the association serum levels of selenium (Se) and copper (Cu) with symptoms and IgG immune response to SARS-CoV-2. Blood samples and nasopharyngeal swabs were obtained from 126 COVID-19 patients with mild and severe symptoms. The serum levels of Cu and Se were measured by atomic-absorption spectrophotometry. Mean Se was higher in patients with mild symptoms and IgG nonresponders, whereas mean Cu was higher in patients with severe symptoms and IgG responders. The Cu/Se ratio was lower in patients with no IgG responses to infection and mild symptoms versus IgG responders with severe symptoms. These results suggest the Cu/Se ratio as a nutritional biomarker of severity and IgG immune response in COVID-19 patients.
评估血清硒（Se）和铜（Cu）水平与 SARS-CoV-2 症状和 IgG 免疫反应的关系。采集 126 例轻症和重症 COVID-19 患者的血样和鼻咽拭子。采用原子吸收分光光度法测定血清中 Cu 和 Se 水平。症状较轻和 IgG 无应答者的 Se 均值较高，而症状较重和 IgG 应答者的 Cu 均值较高。无 IgG 对感染应答且症状较轻的患者与 IgG 应答且症状较重的患者相比，Cu/Se 比值较低。这些结果提示 Cu/Se 比值可作为 COVID-19 患者严重程度和 IgG 免疫反应的营养生物标志物。
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