Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, D-10115 Berlin, Germany; Berlin Institute of Health (BIH), Biomedical Innovation Academy (BIA), D-10117 Berlin, Germany.
Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, D-10115 Berlin, Germany.
Redox Biol. 2022 Apr;50:102242. doi: 10.1016/j.redox.2022.102242. Epub 2022 Feb 3.
The essential trace element selenium (Se) is of central importance for human health and particularly for a regular functioning of the immune system. In the context of the current pandemic, Se deficiency in patients with COVID-19 correlated with disease severity and mortality risk. Selenium has been reported to be associated with the immune response following vaccination, but it is unknown whether this also applies to SARS-CoV-2 vaccines. In this observational study, adult health care workers (n = 126) who received two consecutive anti-SARS-CoV-2 vaccinations by BNT162b2 were followed for up to 24 weeks, with blood samples collected at the first and second dose and at three and 21 weeks after the second dose. Serum SARS-CoV-2 IgG titres, neutralising antibody potency, total Se and selenoprotein P concentrations, and glutathione peroxidase 3 activity were quantified. All three biomarkers of Se status were significantly correlated at all the time points, and participants who reported supplemental Se intake displayed higher Se concentrations. SARS-CoV-2 IgG titres and neutralising potency were highest three weeks after the second dose and decreased towards the last sampling point. The humoral immune response was not related to any of the three Se status biomarkers. Supplemental Se intake had no effect at any time point on the vaccination response as measured by serum SARS-CoV-2 IgG levels or neutralising potency. Overall, no association was found between Se status or supplemental Se intake and humoral immune response to COVID-19 mRNA vaccination.
必需微量元素硒（Se）对人类健康至关重要，尤其对免疫系统的正常功能至关重要。在当前大流行的背景下，COVID-19 患者的硒缺乏与疾病严重程度和死亡风险相关。有报道称，硒与接种疫苗后的免疫反应有关，但尚不清楚这是否也适用于 SARS-CoV-2 疫苗。在这项观察性研究中，126 名接受了两剂 BNT162b2 连续抗 SARS-CoV-2 疫苗接种的成年保健工作者在接种后最多 24 周内进行了随访，在第一剂和第二剂以及第二剂后 3 周和 21 周采集了血样。定量检测了血清 SARS-CoV-2 IgG 滴度、中和抗体效价、总硒和硒蛋白 P 浓度以及谷胱甘肽过氧化物酶 3 活性。所有三种硒状态生物标志物在所有时间点均呈显著相关性，报告补充硒摄入的参与者显示出更高的硒浓度。SARS-CoV-2 IgG 滴度和中和效价在第二剂后 3 周最高，并在最后一次采样时下降。体液免疫反应与三种硒状态生物标志物中的任何一种均无关。补充硒在任何时间点对血清 SARS-CoV-2 IgG 水平或中和效价测量的疫苗反应均无影响。总体而言，硒状态或补充硒摄入与 COVID-19 mRNA 疫苗接种的体液免疫反应之间未发现相关性。
