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国家艾滋病病毒检测计划建议。

National HIV programme testing recommendations.

作者信息

Choy Chiaw Yee, Wong Chen Seong, Kumar P Arun, Lin Raymond Tzer Pin, Low Carmen, Toh Matthias Paul Han Sim, Huang Flora, Olszyna Dariusz Piotr, Teh Yii Ean, Chien Mei Fong Jaime, Archuleta Sophia

机构信息

Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore.

National Centre for Infectious Diseases, Singapore.

出版信息

Singapore Med J. 2025 Jun 1;66(6):294-300. doi: 10.4103/singaporemedj.SMJ-2021-466. Epub 2023 May 19.

DOI:10.4103/singaporemedj.SMJ-2021-466
PMID:37338488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12200811/
Abstract

In recognition of the morbidity and mortality associated with human immunodeficiency virus (HIV), the Joint United Nations Programme on HIV/acquired immunodeficiency syndrome (AIDS) (UNAIDS) aims to end the epidemic by setting and striving to achieve the ambitious 95-95-95 targets. However, Singapore is still not performing well in the first UNAIDS target. The National HIV Programme (NHIVP) developed this set of recommendations based on an adaptation of major international guidelines from the World Health Organization and the US Centers for Disease Control and Prevention. The goals of this recommendation are: (1) to increase the uptake of HIV testing; (2) to allow earlier detection and identification of individuals with unrecognised HIV infection; (3) to facilitate linkage to clinical services; and (4) reduce further transmission of HIV infection in Singapore.

摘要

认识到与人类免疫缺陷病毒(HIV)相关的发病率和死亡率,联合国艾滋病毒/后天免疫机能丧失综合症(艾滋病)联合规划署(UNAIDS)旨在通过设定并努力实现宏伟的95-95-95目标来终结这一流行病。然而,新加坡在UNAIDS的首个目标方面仍表现不佳。国家艾滋病毒项目(NHIVP)基于对世界卫生组织和美国疾病控制与预防中心的主要国际准则的改编制定了这套建议。本建议的目标是:(1)提高艾滋病毒检测的接受度;(2)更早地检测和识别未被认识到感染艾滋病毒的个体;(3)促进与临床服务的联系;以及(4)减少艾滋病毒感染在新加坡的进一步传播。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f99/12200811/f874390c9dd3/SMJ-66-294-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f99/12200811/f874390c9dd3/SMJ-66-294-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f99/12200811/f874390c9dd3/SMJ-66-294-g001.jpg

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本文引用的文献

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Rapid initiation of antiretroviral therapy for people living with HIV.为艾滋病毒感染者迅速启动抗逆转录病毒治疗。
Cochrane Database Syst Rev. 2019 Jun 17;6(6):CD012962. doi: 10.1002/14651858.CD012962.pub2.
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新加坡登革热样发热疾病中艾滋病毒检测的高检出率
Open Forum Infect Dis. 2018 Jul 13;5(8):ofy171. doi: 10.1093/ofid/ofy171. eCollection 2018 Aug.
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HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART.HIV DNA设定点在急性HIV感染中迅速确立,并通过早期抗逆转录病毒治疗显著降低。
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Initiation of Antiretroviral Therapy During Acute HIV-1 Infection Leads to a High Rate of Nonreactive HIV Serology.急性 HIV-1 感染时启动抗逆转录病毒治疗可导致高比例的 HIV 血清学无反应。
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Early Initiation Rather Than Prolonged Duration of Antiretroviral Therapy in HIV Infection Contributes to the Normalization of CD8 T-Cell Counts.在HIV感染中,抗逆转录病毒治疗的早期启动而非长期持续时间有助于CD8 T细胞计数正常化。
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