The Dublin Neurological Institute, Mater Misericordiae University Hospital, Dublin, Ireland.
Department of Neurology, St Vincent's University Hospital, Dublin, Ireland.
Adv Neurobiol. 2023;31:177-194. doi: 10.1007/978-3-031-26220-3_10.
Adult-onset isolated focal dystonia (AOIFD) is a network disorder characterised by abnormalities of sensory processing and motor control. These network abnormalities give rise to both the phenomenology of dystonia and the epiphenomena of altered plasticity and loss of intracortical inhibition. Existing modalities of deep brain stimulation effectively modulate parts of this network but are limited both in terms of targets and invasiveness. Novel approaches using a variety of non-invasive neuromodulation techniques including transcranial stimulation and peripheral stimulation present an interesting alternative approach and may, in conjunction with rehabilitative strategies, have a role in tailored therapies targeting the underlying network abnormality behind AOIFD.
成人发作性局灶性肌张力障碍（AOIFD）是一种以感觉处理和运动控制异常为特征的网络障碍。这些网络异常导致了肌张力障碍的表现和异常可塑性以及皮质内抑制丧失的继发现象。现有的深部脑刺激模式有效地调节了这个网络的部分功能，但在靶点和侵袭性方面都存在局限性。使用各种非侵入性神经调节技术，包括经颅刺激和外周刺激的新方法提供了一种有趣的替代方法，并且可能与康复策略一起，在针对 AOIFD 背后的潜在网络异常的定制治疗中发挥作用。
