作为一种神经网络障碍的肌张力障碍的临床意义。
Clinical Implications of Dystonia as a Neural Network Disorder.
机构信息
Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA.
Department of Neurology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA.
出版信息
Adv Neurobiol. 2023;31:223-240. doi: 10.1007/978-3-031-26220-3_13. Epub 2023 Jun 21.
Abstract
Isolated dystonia is a neurological disorder of diverse etiology, multifactorial pathophysiology, and wide spectrum of clinical presentations. We review the recent neuroimaging advances that led to the conceptualization of dystonia as a neural network disorder and discuss how current knowledge is shaping the identification of biomarkers of dystonia and the development of novel pharmacological therapies.
摘要
孤立性肌张力障碍是一种病因多样、发病机制多因素、临床表现广泛的神经障碍。我们回顾了最近的神经影像学进展，这些进展使人们将肌张力障碍概念化为一种神经网络障碍，并讨论了当前的知识如何塑造肌张力障碍生物标志物的识别和新型药物治疗的发展。
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