嘧啶受体在胞磷胆碱神经保护作用机制中的作用。

The Role of PY Receptors in the Mechanisms of the Neuroprotective Effect of Citicoline.

机构信息

Department of Pharmacology, Tyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.

Federal Center of Neurosurgery, Ministry of Health of the Russian Federation, Tyumen, Russia.

出版信息

Bull Exp Biol Med. 2023 May;175(1):45-48. doi: 10.1007/s10517-023-05808-z. Epub 2023 Jun 20.

DOI:10.1007/s10517-023-05808-z

PMID:37338760

Abstract

Spontaneous bioelectrical activity of the brain and the duration of gasping were recorded in mice during modeling of global strangulation ischemia of the brain against the background of preventive administration of citicoline. The maximum neuroprotective effect of citicoline was observed when it was administered 60 min before the simulation of ischemia and was completely prevented by preliminary administration of a selective PY receptor antagonist MRS2578. The obtained experimental data attest to the leading role of receptor mechanisms in the implementation of neuroprotective activity of citicoline.

摘要

在对脑全局缺血缺氧模型进行建模时，记录了老鼠的大脑自发生物电活动和喘息持续时间，同时还预防性地给予了胞磷胆碱。当胞磷胆碱在模拟缺血前 60 分钟给予时，观察到其最大的神经保护作用，而预先给予选择性 PY 受体拮抗剂 MRS2578 则完全阻止了这一作用。所得实验数据证明了受体机制在胞磷胆碱的神经保护活性中的主导作用。