Khan Yasser Saeed, Khoodoruth Mohamed Adil Shah, Albobali Yahia, Haddad Peter M
Child and Adolescent Mental Health Service, Hamad Medical Corporation, Doha, Qatar.
Division of Genomics and Precision Medicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Doha, Qatar.
Expert Opin Drug Saf. 2023 Jan-Jun;22(5):381-390. doi: 10.1080/14740338.2023.2224557. Epub 2023 Jun 20.
While there is considerable published evidence regarding the nature and severity of Selective Serotonin Reuptake Inhibitor (SSRI) discontinuation symptoms in the adult population, information relating to the child and adolescent population remains scarce. This narrative review examined the published literature on SSRI withdrawal symptoms in the under-18-year-old age group. MEDLINE and PsycINFO were comprehensively searched from inception to 5 May 2023.
This review highlights the importance of recognizing SSRI withdrawal in children and adolescents and summarizes available literature and guidelines for safe discontinuation.
Evidence of the presence of SSRI withdrawal phenomenon in children and adolescents mainly originates from case reports and extrapolated adult data. Existing data on SSRI withdrawal syndrome in children and adolescents is therefore limited, and there is a need for formal research in this specific population to establish with more certainty the nature and extent of SSRI withdrawal syndrome. Nevertheless, there is currently enough evidence available for prescribing clinicians to provide psychoeducation to patients and families about the possibility of withdrawal symptoms when SSRI treatment is considered. The need for gradual and planned discontinuation should also be discussed for safe withdrawal.
虽然已有大量关于成人选择性5-羟色胺再摄取抑制剂（SSRI）停药症状的性质和严重程度的证据，但有关儿童和青少年人群的信息仍然匮乏。本叙述性综述研究了18岁以下年龄组中关于SSRI戒断症状的已发表文献。对MEDLINE和PsycINFO从创刊至2023年5月5日进行了全面检索。
本综述强调了识别儿童和青少年中SSRI戒断的重要性，并总结了关于安全停药的现有文献和指南。
儿童和青少年中存在SSRI戒断现象的证据主要来自病例报告和外推的成人数据。因此，关于儿童和青少年中SSRI戒断综合征的现有数据有限，需要在这一特定人群中进行正式研究，以更确定地确定SSRI戒断综合征的性质和程度。然而，目前已有足够的证据供开处方的临床医生向患者及其家属提供关于在考虑使用SSRI治疗时出现戒断症状可能性的心理教育。为了安全停药，还应讨论逐渐和有计划停药的必要性。
