Symbiosis School of Biological Sciences, Symbiosis International (Deemed University), Pune, Maharashtra, India.
Crit Rev Microbiol. 2024 Aug;50(4):504-513. doi: 10.1080/1040841X.2023.2223277. Epub 2023 Jun 20.
One of the main issues in modern medicine is the decrease in the efficacy of antibiotic therapy against resistant microorganisms. The advent of antimicrobial resistance has added significantly to the impact of infectious diseases, in number of infections, as well as added healthcare costs. The development of antibiotic tolerance and resistance is influenced by a variety of environmental variables, and it is important to identify these environmental factors as part of any strategy for combating antibiotic resistance. The review aims to emphasize that biogenic polyamines are one of such environmental cues that impacts the antibiotic resistance in bacteria. The biogenic polyamines can help bacteria acquire resistance to antibiotics either by regulating the level of number of porin channels in the outer membrane, by modifying the outer membrane liposaccharides or by protecting macromolecule from antibiotic stress. Thus, understanding the way polyamines function in bacteria can thus be beneficial while designing the drugs to combat diseases.
现代医学中的一个主要问题是抗生素疗法对耐药微生物的疗效下降。抗菌药物耐药性的出现显著增加了传染病的影响，包括感染的数量，并增加了医疗保健成本。抗生素耐药性的发展受到多种环境变量的影响，因此，确定这些环境因素是任何对抗抗生素耐药性策略的重要组成部分。本综述旨在强调生物源多胺是影响细菌对抗生素耐药性的环境线索之一。生物源多胺可以通过调节外膜中孔道的数量和种类，改变外膜脂多糖，或保护大分子免受抗生素应激，帮助细菌获得抗生素耐药性。因此，了解多胺在细菌中的作用方式对于设计对抗疾病的药物可能是有益的。
