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妊娠合并垂体卒中:我们了解多少?

Pituitary Apoplexy in Pregnancy: What do We Know?

机构信息

Hospital Beatriz Ângelo, Loures, Portugal.

出版信息

Rev Bras Ginecol Obstet. 2023 May;45(5):273-280. doi: 10.1055/s-0043-1770128. Epub 2023 Jun 20.

DOI:10.1055/s-0043-1770128
PMID:37339647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10442903/
Abstract

Pituitary apoplexy refers to a rare clinical syndrome consisting of signs and symptoms that occur due to rapid expansion of the contents of the . It can occur spontaneously or associated with pituitary tumors. It can have a broad clinical spectrum, but usually presents with severe headache, visual impairment and hypopituitarism. Sudden onset of symptoms associated to imagiologic confirmation makes the diagnosis. Surgical treatment is advised when there is important compression of the optic tract. We present a case report and a review of the literature on pituitary apoplexy in pregnancy. The cases were reviewed to obtain information on maternal characteristics, clinical presentation, diagnostic studies, therapeutic modalities and maternal and fetal outcomes. Our review found 36 cases of pituitary apoplexy in pregnancy. Most of the cases occurred in the second trimester of pregnancy and headache was the most frequent symptom at presentation. Surgical therapy was required in more than half of the patients. In what respect maternal and fetal outcomes, there were 3 cases of preterm delivery and one case of maternal death. Our clinical case and literature review reinforces the importance of an early diagnosis to avoid potential adverse consequences.

摘要

垂体卒中是一种罕见的临床综合征,其特征为由于 的内容物迅速扩张而引起的体征和症状。它可以自发发生,也可以与垂体瘤有关。它可以具有广泛的临床谱,但通常表现为严重头痛、视力障碍和垂体功能减退。症状的突然出现并结合影像学证实可做出诊断。当视神经束受到严重压迫时,建议进行手术治疗。我们报告了一例妊娠合并垂体卒中的病例,并对文献进行了复习。对病例进行了回顾,以获取有关孕产妇特征、临床表现、诊断研究、治疗方式以及母婴结局的信息。我们的复习发现了 36 例妊娠合并垂体卒中。大多数病例发生在妊娠中期,头痛是最常见的首发症状。超过一半的患者需要手术治疗。在母婴结局方面,有 3 例早产和 1 例产妇死亡。我们的临床病例和文献复习都强调了早期诊断的重要性,以避免潜在的不良后果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d872/10442903/051930d9f695/10-1055-s-0043-1770128-i220045-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d872/10442903/d829deb52df2/10-1055-s-0043-1770128-i220045-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d872/10442903/051930d9f695/10-1055-s-0043-1770128-i220045-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d872/10442903/d829deb52df2/10-1055-s-0043-1770128-i220045-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d872/10442903/051930d9f695/10-1055-s-0043-1770128-i220045-2.jpg

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Unveiling postpartum pituitary apoplexy through atypical presentation: A case report and review of literature.通过非典型表现揭示产后垂体卒中:一例病例报告及文献综述
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Morbidities and mortality among hospitalized patients with hypopituitarism: Prevalence, causes and management.

本文引用的文献

1
Pituitary apoplexy associated with acute COVID-19 infection and pregnancy.与急性 COVID-19 感染和妊娠相关的垂体卒中。
Pituitary. 2020 Dec;23(6):716-720. doi: 10.1007/s11102-020-01080-w. Epub 2020 Sep 11.
2
Surgical indications for pituitary tumors during pregnancy: a literature review.妊娠期间垂体瘤的手术适应证:文献综述。
Pituitary. 2020 Apr;23(2):189-199. doi: 10.1007/s11102-019-01004-3.
3
A case of atypical macroprolactinoma presenting with pituitary apoplexy during pregnancy and review of the literature.一例妊娠期间发生垂体卒中的不典型大泌乳素腺瘤病例报告并文献复习。
住院垂体功能减退症患者的发病率、病因和治疗。
Rev Endocr Metab Disord. 2024 Jun;25(3):599-608. doi: 10.1007/s11154-024-09888-8. Epub 2024 May 27.
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Pituitary Apoplexy: An Updated Review.垂体卒中:最新综述
J Clin Med. 2024 Apr 24;13(9):2508. doi: 10.3390/jcm13092508.
Gynecol Endocrinol. 2020 Feb;36(2):109-116. doi: 10.1080/09513590.2019.1650339. Epub 2019 Aug 7.
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Gestational pituitary apoplexy: Case series and review of the literature.妊娠性垂体卒中:病例系列及文献综述
J Gynecol Obstet Hum Reprod. 2019 Dec;48(10):873-881. doi: 10.1016/j.jogoh.2019.05.005. Epub 2019 May 3.
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Prolactinoma and pregnancy - a series of cases including pituitary apoplexy.泌乳素瘤与妊娠——包括垂体卒中的一系列病例
J Obstet Gynaecol. 2017 Apr;37(3):284-287. doi: 10.1080/01443615.2016.1233946. Epub 2016 Nov 21.
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Complex effects of apoplexy secondary to pituitary adenoma.垂体腺瘤继发中风的复杂影响。
Rev Neurosci. 2017 Jan 1;28(1):59-64. doi: 10.1515/revneuro-2016-0013.
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Pituitary apoplexy in pregnancy: A case series and literature review.妊娠期垂体卒中:病例系列报道及文献综述
Obstet Med. 2015 Dec;8(4):177-83. doi: 10.1177/1753495X15598917. Epub 2015 Sep 22.
8
Spontaneous pituitary apoplexy during the second trimester of pregnancy, with sensory loss.妊娠中期自发性垂体卒中伴感觉丧失。
BMJ Case Rep. 2016 Feb 16;2016:bcr2015212405. doi: 10.1136/bcr-2015-212405.
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Endoscopic Endonasal Transsphenoidal Resection for Pituitary Apoplexy during the Third Trimester of Pregnancy.孕晚期垂体卒中的鼻内镜经蝶窦切除术
Surg Res Pract. 2014;2014:397131. doi: 10.1155/2014/397131. Epub 2014 Jan 2.
10
A case of pituitary apoplexy in pregnancy.妊娠期间垂体卒中一例。
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