Zhang Dan-Dan, Wang Zi-Yi, Zhang Ya-Ru, Gao Pei-Yang, Zhang Wei, Fu Yan, Chi Hao-Chen, Ma Li-Yun, Ge Yi-Jun, He Xiao-Yu, You Jia, Cheng Wei, Feng Jian-Feng, Tan Lan, Yu Jin-Tai
Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Department of Neurology and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, China.
J Transl Med. 2024 Dec 31;22(1):1172. doi: 10.1186/s12967-024-06006-9.
Epilepsy, as a chronic noncommunicable disease with recurrent seizures, may be a marker of deterioration or alteration in other underlying neurological diseases. This study aimed to investigate the relationship of epilepsy with brain function, other common brain disorders, and their underlying mechanisms.
The study was based on clinical diagnostic and test data from 426,527 participants in the UK Biobank, of whom 3,251 were diagnosed with epilepsy at baseline. Multiple linear and Cox regression models were used to explore the association between epilepsy, brain function, and other brain disorders.
This study demonstrated consistent deleterious effects of epilepsy on cognitive and motor function and mental health. The risk of neurological diseases and psychiatric disorders was significantly elevated in the epilepsy population during the 17-year follow-up period, according to the longitudinal analysis. We also identified several brain regions associated with epilepsy, including the pallidum, hippocampus, and precentral regions. Mediation analyses revealed mediating effects of peripheral markers and proteins (e.g., GGT, HDL, ACE2, and GDF15), suggesting that liver function and lipid metabolism may be involved in the development of other brain disorders in individuals with epilepsy.
Our study provides robust evidence of the association between epilepsy and poor brain health, underscoring the importance of early intervention for epilepsy.
癫痫作为一种具有反复发作性的慢性非传染性疾病，可能是其他潜在神经系统疾病恶化或改变的一个标志。本研究旨在探讨癫痫与脑功能、其他常见脑部疾病及其潜在机制之间的关系。
该研究基于英国生物银行中426,527名参与者的临床诊断和测试数据，其中3251人在基线时被诊断为癫痫。使用多元线性回归模型和Cox回归模型来探讨癫痫、脑功能和其他脑部疾病之间的关联。
本研究证明了癫痫对认知、运动功能和心理健康具有持续的有害影响。根据纵向分析，在17年的随访期内，癫痫患者群体中神经疾病和精神疾病的风险显著升高。我们还确定了几个与癫痫相关的脑区，包括苍白球、海马体和中央前回区域。中介分析揭示了外周标志物和蛋白质（如γ-谷氨酰转移酶、高密度脂蛋白、血管紧张素转换酶2和生长分化因子15）的中介作用，表明肝功能和脂质代谢可能参与癫痫患者其他脑部疾病的发生发展。
我们的研究为癫痫与脑健康不良之间的关联提供了有力证据，强调了癫痫早期干预的重要性。
