Department of Immunology, Zhuhai Campus of Zunyi Medical University, Zhuhai, China.
Department of Pharmacy, Zhuhai Campus of Zunyi Medical University, Zhuhai, China.
Dokl Biochem Biophys. 2023 Apr;509(1):81-85. doi: 10.1134/S1607672922600166. Epub 2023 Jun 20.
Fucoxanthin (FX) has been reported to reduce mortality in mouse models of sepsis, but its exact cause remains to be determined. In the present study, we evaluated the immunomodulatory properties of FX in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Our results showed that FX could not only suppress the immune activation responses caused by LPS primary stimulation, but also antagonize LPS restimulation-induced immunosuppression in macrophages. The immunomodulatory capabilities of FX was mainly demonstrated by regulating the production of the inflammatory mediator under different LPS stimuli. Furthermore, we found that adenosine monophosphate-activated protein kinase (AMPK) activation was required for FX's anti-inflammatory and anti-immunosuppressive activities. Our results complement existing data supporting the clinical potential for FX in treating sepsis.
褐藻黄素（FX）已被报道可降低脓毒症小鼠模型的死亡率，但确切原因仍有待确定。在本研究中，我们评估了 FX 在脂多糖（LPS）刺激的 RAW 264.7 细胞中的免疫调节特性。我们的结果表明，FX 不仅可以抑制 LPS 初次刺激引起的免疫激活反应，还可以拮抗 LPS 再刺激诱导的巨噬细胞免疫抑制。FX 的免疫调节能力主要通过调节不同 LPS 刺激下炎症介质的产生来体现。此外，我们发现 FX 的抗炎和抗免疫抑制活性需要激活单磷酸腺苷激活的蛋白激酶（AMPK）。我们的结果补充了现有的数据，支持 FX 在治疗脓毒症方面的临床潜力。
