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Towards precision medicine for sepsis patients.

作者信息

Pickkers Peter, Kox Matthijs

机构信息

Department of Intensive Care Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Internal mail 710, P.O. Box 9101, Nijmegen, 6500 HB, The Netherlands.

Radboud Center for Infectious Diseases (RCI), Nijmegen, The Netherlands.

出版信息

Crit Care. 2017 Jan 12;21(1):11. doi: 10.1186/s13054-016-1583-z.

DOI:10.1186/s13054-016-1583-z
PMID:28077168
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5228110/
Abstract
摘要

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本文引用的文献

1
Comparison of monocyte human leukocyte antigen-DR expression and stimulated tumor necrosis factor alpha production as outcome predictors in severe sepsis: a prospective observational study.单核细胞人类白细胞抗原-DR表达及刺激后肿瘤坏死因子α产生作为严重脓毒症预后预测指标的比较：一项前瞻性观察性研究
Crit Care. 2016 Oct 20;20(1):334. doi: 10.1186/s13054-016-1505-0.
2
Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1.前沿科学：脓毒症患者的免疫功能缺陷与PD-1或PD-L1表达相关，且可通过靶向PD-1或PD-L1的抗体得以恢复。
J Leukoc Biol. 2016 Dec;100(6):1239-1254. doi: 10.1189/jlb.4HI0616-255R. Epub 2016 Sep 26.
3
Monocyte programmed death ligand-1 expression after 3-4 days of sepsis is associated with risk stratification and mortality in septic patients: a prospective cohort study.脓毒症3 - 4天后单核细胞程序性死亡配体-1表达与脓毒症患者的风险分层及死亡率相关：一项前瞻性队列研究
Crit Care. 2016 May 9;20(1):124. doi: 10.1186/s13054-016-1301-x.
4
Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis.严重脓毒症患者白细胞能量代谢存在广泛缺陷，导致免疫麻痹。
Nat Immunol. 2016 Apr;17(4):406-13. doi: 10.1038/ni.3398. Epub 2016 Mar 7.
5
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).《脓毒症及脓毒性休克第三次国际共识定义（脓毒症-3）》
JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287.
6
Sepsis-induced immune dysfunction: can immune therapies reduce mortality?脓毒症诱导的免疫功能障碍：免疫疗法能否降低死亡率？
J Clin Invest. 2016 Jan;126(1):23-31. doi: 10.1172/JCI82224. Epub 2016 Jan 4.
7
Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial.白细胞介素-1受体阻断与具有巨噬细胞活化综合征特征的脓毒症患者死亡率降低相关：对一项既往III期试验的重新分析
Crit Care Med. 2016 Feb;44(2):275-81. doi: 10.1097/CCM.0000000000001402.
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Immune checkpoint blockade: a common denominator approach to cancer therapy.免疫检查点阻断：癌症治疗的一种通用方法。
Cancer Cell. 2015 Apr 13;27(4):450-61. doi: 10.1016/j.ccell.2015.03.001. Epub 2015 Apr 6.
9
Reactivation of multiple viruses in patients with sepsis.脓毒症患者中多种病毒的再激活。
PLoS One. 2014 Jun 11;9(2):e98819. doi: 10.1371/journal.pone.0098819. eCollection 2014.
10
Why have clinical trials in sepsis failed?为什么脓毒症临床试验会失败？
Trends Mol Med. 2014 Apr;20(4):195-203. doi: 10.1016/j.molmed.2014.01.007. Epub 2014 Feb 24.