Chen Dong-Yang, Han Qing-Rong, Sheng Hai-Yan
School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.
Sheng Li Xue Bao. 2023 Jun 25;75(3):475-485.
Pain is a multi-dimensional emotional experience, and pain sensation and pain emotion are the two main components. As for pain, previous studies only focused on a certain link of the pain transmission pathway or a certain key brain region, and there is a lack of evidence that connectivity of brain regions is involved in pain or pain regulation in the overall state. The establishment of new experimental tools and techniques has brought light to the study of neural pathways of pain sensation and pain emotion. In this paper, the structure and functional basis of the neural pathways involved in the formation of pain sensation and the regulation of pain emotion in the nervous system above the spinal cord level, including thalamus, amygdala, midbrain periaqueductal gray (PAG), parabrachial nucleus (PB) and medial prefrontal cortex (mPFC), are reviewed in recent years, providing clues for the in-depth study of pain.
疼痛是一种多维度的情感体验，痛觉和痛情绪是其两个主要组成部分。关于疼痛，以往的研究仅聚焦于疼痛传导通路的某一环节或某个关键脑区，缺乏证据表明脑区之间的连接性在整体状态下参与疼痛或疼痛调节。新实验工具和技术的建立为痛觉和痛情绪神经通路的研究带来了曙光。本文综述了近年来脊髓以上神经系统中参与痛觉形成和痛情绪调节的神经通路的结构和功能基础，包括丘脑、杏仁核、中脑导水管周围灰质（PAG）、臂旁核（PB）和内侧前额叶皮质（mPFC），为深入研究疼痛提供线索。
