端粒长度和变化与认知能力下降的关联受性别和种族影响：REGARDS 研究。
Associations of Telomere Length and Change With Cognitive Decline Were Modified by Sex and Race: The REGARDS Study.
机构信息
Department of Obstetrics and Gynecology, Vagelos College of Physician and Surgeons, Columbia University, New York, NY, USA.
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
出版信息
Am J Alzheimers Dis Other Demen. 2023 Jan-Dec;38:15333175231175797. doi: 10.1177/15333175231175797.
INTRODUCTION
We examined the associations of baseline telomere length (TL) and TL change with cognitive function over time in older US adults, as well as differences by sex and race.
METHODS
A total of 1820 cognitively healthy individuals (median baseline age: 63 years) were included. Telomere length was measured using qPCR-based method at baseline and among 614 participants in the follow-up examination 10 years later. Cognitive function was assessed by a four-test battery every 2 years.
RESULTS
In multivariable-adjusted linear mixed models, longer baseline TL and smaller attrition/lengthening of TL over time were associated with better Animal Fluency Test score. Longer baseline TL was also linearly associated with better Letter Fluency Test score. The observed associations were consistently more pronounced in women than men and in Black compared to White participants.
DISCUSSION
Telomere length may be a biomarker that predicts long-term verbal fluency and executive function, particularly in women and Black Americans.
简介
我们研究了美国老年人中基线端粒长度 (TL) 和 TL 变化与随时间推移的认知功能之间的关联，以及性别和种族差异。
方法
共纳入 1820 名认知健康的个体（中位基线年龄：63 岁）。使用基于 qPCR 的方法在基线和 10 年后的随访检查中测量端粒长度。认知功能每 2 年通过四项测试进行评估。
结果
在多变量调整的线性混合模型中，较长的基线 TL 和随时间的 TL 损耗/延长较少与更好的动物流畅性测试评分相关。较长的基线 TL 也与更好的字母流畅性测试评分呈线性相关。在女性和黑人参与者中，观察到的关联比男性和白人参与者更为明显。
讨论
端粒长度可能是预测长期言语流畅性和执行功能的生物标志物，尤其是在女性和美国黑人中。
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