光蝶呤的制备及合成应用。
Preparation and Synthetic Applications of Phototropone.
机构信息
Department of Chemistry, Lancaster University, Bailrigg, LA1 4YB, U.K.
出版信息
J Org Chem. 2023 Jul 7;88(13):9514-9517. doi: 10.1021/acs.joc.3c00590. Epub 2023 Jun 21.
Abstract
An optimized multigram-scale route to phototropone (bicyclo[3.2.0]hepta-2,6-dien-7-one) is reported via the 4-π-photocyclization of tropone complexed to Lewis acid. Phototropone is a highly versatile molecular building block, and its conversion into 18 novel derivatives using standard transformations is demonstrated, allowing access to a variety of rigid bicyclic scaffolds.
摘要
报道了一种优化的多克规模路线，通过与路易斯酸络合的 tropone 的 4-π-光环化反应来合成 phototropone（bicyclo[3.2.0]hepta-2,6-dien-7-one）。Phototropone 是一种非常通用的分子砌块，通过使用标准转化将其转化为 18 种新型衍生物，展示了其转化为 18 种新型衍生物的能力，从而可以获得各种刚性双环支架。
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