Gaviria M, Gil A A, Javaid J I
J Clin Psychopharmacol. 1986 Aug;6(4):227-31.
Nortriptyline kinetics are compared between 10 Hispanic and 10 Anglo healthy, nondepressed volunteers matched for age, sex, and weight. All subjects were given a single oral dose of 75 mg of nortriptyline, and blood samples were drawn at various times over the next 96 hours. Nortriptyline concentration in plasma was determined by gas chromatography with nitrogen detector. From the nortriptyline concentration in plasma and time curve, various kinetic parameters were computed for each individual. There were large interindividual differences in various kinetic parameters. However, no statistically significant differences were found in any of the kinetic parameters between the Hispanic and Anglo groups. These results suggest that there are no major differences in pharmacokinetics and that purported hypersensitivity in Hispanic depressed patients to antidepressant treatment may be due to receptor hypersensitivity.
对10名西班牙裔和10名盎格鲁健康、无抑郁的志愿者进行了去甲替林动力学比较，这些志愿者在年龄、性别和体重方面相互匹配。所有受试者均口服75毫克去甲替林单剂量，在接下来的96小时内不同时间采集血样。采用带氮检测器的气相色谱法测定血浆中去甲替林浓度。根据血浆中去甲替林浓度和时间曲线，为每个个体计算各种动力学参数。各种动力学参数存在较大的个体间差异。然而，西班牙裔和盎格鲁族组之间在任何动力学参数上均未发现统计学上的显著差异。这些结果表明，药代动力学没有重大差异，西班牙裔抑郁症患者对抗抑郁治疗所谓的超敏反应可能是由于受体超敏反应。
