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Pharmacokinetics of nortriptyline in man after single and multiple oral doses: the predictability of steady-state plasma concentrations from single-dose plasma-level data.

作者信息

Alexanderson B

出版信息

Eur J Clin Pharmacol. 1972 Mar;4(2):82-91. doi: 10.1007/BF00562502.

DOI:10.1007/BF00562502
PMID:4655685
Abstract
摘要

相似文献

1
Pharmacokinetics of nortriptyline in man after single and multiple oral doses: the predictability of steady-state plasma concentrations from single-dose plasma-level data.单剂量和多剂量口服后去甲替林在人体内的药代动力学：根据单剂量血浆水平数据预测稳态血浆浓度
Eur J Clin Pharmacol. 1972 Mar;4(2):82-91. doi: 10.1007/BF00562502.
2
Pharmacokinetics of single oral doses of nortriptyline in depressed elderly hospital patients and young healthy volunteers.单剂量口服去甲替林在老年抑郁症住院患者和年轻健康志愿者中的药代动力学。
Clin Pharmacokinet. 1980 Jul-Aug;5(4):394-401. doi: 10.2165/00003088-198005040-00007.
3
Prediction of steady-state plasma levels of nortriptyline from single oral dose kinetics: a study in twins.从单次口服剂量动力学预测去甲替林的稳态血浆水平：一项双胞胎研究。
Eur J Clin Pharmacol. 1973 Jun;6(1):44-53. doi: 10.1007/BF00561800.
4
First-pass metabolism of nortriptyline in man.
Clin Pharmacol Ther. 1975 Sep;18(3):305-14. doi: 10.1002/cpt1975183305.
5
Pharmacokinetics and biological effects of nortriptyline in man.去甲替林在人体中的药代动力学及生物学效应
Acta Pharmacol Toxicol (Copenh). 1971;29 Suppl 3:255-80. doi: 10.1111/j.1600-0773.1971.tb03306.x.
6
Comparison of single dose kinetics of imipramine, nortriptyline and antipyrine in man.
Psychopharmacology (Berl). 1976 Oct 20;50(1):21-7. doi: 10.1007/BF00634149.
7
Two prospective dosing methods for nortriptyline.去甲替林的两种前瞻性给药方法。
Clin Pharmacokinet. 1984 Nov-Dec;9(6):555-63. doi: 10.2165/00003088-198409060-00005.
8
First pass hydroxylation of nortriptyline: concentrations of parent drug and major metabolites in plasma.去甲替林的首过羟基化作用：血浆中母体药物及主要代谢物的浓度
Eur J Clin Pharmacol. 1977 Mar 11;11(3):219-24. doi: 10.1007/BF00606414.
9
Comparison of observed and predicted bioavailability of nortriptyline in humans following oral administration.
J Pharm Sci. 1975 Jun;64(6):1036-7. doi: 10.1002/jps.2600640635.
10
The kinetics of amitriptyline following single oral dose administration to man.阿米替林单次口服给药于人体后的动力学。
Res Commun Chem Pathol Pharmacol. 1978 Dec;22(3):475-84.

引用本文的文献

1
Optimizing Nortriptyline Dosing: A Comparison between Pharmacogenetics-Based, Phenotype-Based, and Standard Dosing.优化去甲替林剂量：基于药物遗传学、基于表型和标准剂量的比较
Clin Pharmacokinet. 2025 May 25. doi: 10.1007/s40262-025-01528-x.
2
Pharmacokinetics of Antidepressants in Pregnancy.抗抑郁药在妊娠期的药代动力学。
J Clin Pharmacol. 2023 Jun;63 Suppl 1(Suppl 1):S137-S158. doi: 10.1002/jcph.2282.
3
Desipramine, substrate for CYP2D6 activity: population pharmacokinetic model and design elements of drug-drug interaction trials.

本文引用的文献

1
[Functional relations between pharmacokinetic properties and dosage of chemotherapeutic agents].[化疗药物的药代动力学特性与剂量之间的功能关系]
Klin Wochenschr. 1960 Jun 1;38:514-20. doi: 10.1007/BF01482679.
2
Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds.使用丙咪嗪类化合物治疗期间单甲基化三环类抗抑郁药的血浆水平。
Life Sci. 1967 Sep 1;6(17):1895-903. doi: 10.1016/0024-3205(67)90218-4.
3
Application of isotope derivative technique to assay of secondary amines: estimation of desipramine by acetylation with H3-acetic anhydride.
去甲丙咪嗪，CYP2D6 活性的底物：群体药代动力学模型和药物相互作用试验的设计要素。
Br J Clin Pharmacol. 2010 Oct;70(4):523-36. doi: 10.1111/j.1365-2125.2010.03731.x.
4
Therapeutic drug monitoring of nortriptyline in smoking cessation: a multistudy analysis.去甲替林在戒烟治疗中的药物监测：一项多研究分析。
Clin Pharmacol Ther. 2008 Mar;83(3):436-42. doi: 10.1038/sj.clpt.6100307. Epub 2007 Aug 8.
5
Time-dependent inhibition of human drug metabolizing cytochromes P450 by tricyclic antidepressants.三环类抗抑郁药对人药物代谢细胞色素P450的时间依赖性抑制作用。
Br J Clin Pharmacol. 2008 Jan;65(1):87-97. doi: 10.1111/j.1365-2125.2007.02964.x. Epub 2007 Jul 27.
6
Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs.CYP2D6的分子遗传学：聚焦精神药物的临床相关性
Br J Clin Pharmacol. 2002 Feb;53(2):111-22. doi: 10.1046/j.0306-5251.2001.01548.x.
7
Evaluation of truncated areas in the assessment of bioequivalence of immediate release formulations of drugs with long half-lives and of Cmax with different dissolution rates.在评估具有长半衰期的速释制剂的生物等效性以及不同溶出速率的Cmax时对截短面积的评估。
Pharm Res. 1999 Jun;16(6):939-43. doi: 10.1023/a:1018898624643.
8
Chirality and drugs used in psychiatry: nice to know or need to know?精神病学中使用的手性与药物：了解即可还是必须了解？
Cell Mol Neurobiol. 1999 Jun;19(3):355-72. doi: 10.1023/a:1006997731966.
9
Pharmacokinetic interaction between diltiazem and nortriptyline.
Eur J Clin Pharmacol. 1996;49(5):417-9. doi: 10.1007/BF00203789.
10
Population pharmacokinetics and pharmacodynamics: potential use for gathering dose-concentration-response.
Eur J Drug Metab Pharmacokinet. 1996 Apr-Jun;21(2):113-21. doi: 10.1007/BF03190259.
同位素衍生技术在仲胺测定中的应用：用H3-乙酸酐乙酰化法测定地昔帕明
J Pharmacol Exp Ther. 1967 Sep;157(3):503-8.
4
Blood levels of drug at the equilibrium state after multiple dosing.多次给药后达到平衡状态时药物的血药浓度。
Nature. 1965 Sep 18;207(5003):1301-2. doi: 10.1038/2071301a0.
5
A comparative study of the metabolism of desmethylimipramine, nortriptyline, and oxyphenylbutazone in man.
Clin Pharmacol Ther. 1969 Jan-Feb;10(1):44-9. doi: 10.1002/cpt196910144.
6
Pharmacokinetics of accumulation.
J Pharm Sci. 1968 Dec;57(12):2162-5. doi: 10.1002/jps.2600571230.
7
Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment.将人体视为具有单室性质进行药代动力学分析时存在的缺点。
J Pharm Sci. 1968 Jan;57(1):117-23. doi: 10.1002/jps.2600570123.
8
[Fatal poisoning with a small dose of Imipramine in an infant].[婴儿小剂量丙咪嗪致死性中毒]
Schweiz Med Wochenschr. 1971 Jun 12;101(23):851-4.
9
Relationship between plasma level and therapeutic effect of nortriptyline.去甲替林血药浓度与治疗效果的关系。
Br Med J. 1971 Aug 7;3(5770):331-4. doi: 10.1136/bmj.3.5770.331.
10
A report on autopsy cases involving amitriptyline and nortriptyline.一份关于涉及阿米替林和去甲替林尸检病例的报告。
Z Rechtsmed. 1970;67(3):190-200. doi: 10.1007/BF00200359.