DiBartola S P, Tarr M J, Benson M D
J Comp Pathol. 1986 Jul;96(4):387-98. doi: 10.1016/0021-9975(86)90034-4.
The tissue distribution of amyloid deposits was studied in 15 related Abyssinian cats with familial amyloidosis. There was interstitial medullary amyloidosis in the kidneys of all 15 cats but only 11 had detectable glomerular involvement. The thyroid glands, stomach and colon were affected in all cats examined. Most of the cats also had amyloid deposits in the small intestine, spleen, heart, adrenals, pancreas, liver, lymph nodes and bladder. In 50 per cent or fewer of the cats examined, there was involvement of the parathyroids, lung and gonads. The central nervous system was not involved in any of the 3 cats evaluated. In 8 of the cats, no concurrent inflammatory disease could be detected. The tissue distribution of amyloid deposits resembled that found in other breeds of domestic cats with systemic amyloidosis. Despite the wide tissue distribution of amyloid deposits, clinical signs were related to renal amyloidosis. Familial amyloidosis in the Abyssinian cat may represent a valuable spontaneous animal model for the study of Familial Mediterranean Fever in man and the pathogenesis of reactive amyloidosis in general.
对15只患有家族性淀粉样变性的阿比西尼亚猫进行了淀粉样沉积物的组织分布研究。15只猫的肾脏均存在间质性髓质淀粉样变性，但只有11只猫的肾小球有明显受累。所有接受检查的猫的甲状腺、胃和结肠均受到影响。大多数猫的小肠、脾脏、心脏、肾上腺、胰腺、肝脏、淋巴结和膀胱也有淀粉样沉积物。在接受检查的50%或更少的猫中，甲状旁腺、肺和性腺受到累及。在评估的3只猫中，中枢神经系统均未受累。在8只猫中，未检测到并发的炎症性疾病。淀粉样沉积物的组织分布与其他患有全身性淀粉样变性的家猫品种相似。尽管淀粉样沉积物的组织分布广泛，但临床症状与肾淀粉样变性有关。阿比西尼亚猫的家族性淀粉样变性可能是研究人类家族性地中海热和一般反应性淀粉样变性发病机制的有价值的自发动物模型。
