Chew D J, DiBartola S P, Boyce J T, Gasper P W
J Am Vet Med Assoc. 1982 Jul 15;181(2):139-42.
Renal amyloidosis was diagnosed in 8 related Abyssinian cats. The kidneys were characterized pathologically by medullary interstitial and glomerular amyloid deposition, interstitial fibrosis, and papillary necrosis. Amyloid deposits were birefringent under polarized light after Congo red staining, were thioflavine-T positive, and lost Congo red staining after permanganate oxidation. Four of the cats were evaluated clinically. Two of these cats were terminally uremic, with nonregenerative anemia, azotemia, hyperphosphatemia, metabolic acidosis, mild hyperglycemia, isosthenuria, proteinuria, cylindruria, and mild hematuria. The remaining 2 cats were only moderately azotemic. Three of the cats had severe gingivitis and all 4 cats had hyperproteinemia due to hyperglobulinemia.
8只相关的阿比西尼亚猫被诊断出患有肾淀粉样变性。肾脏的病理特征为髓质间质和肾小球淀粉样沉积、间质纤维化和乳头坏死。刚果红染色后，淀粉样沉积物在偏振光下呈双折射，硫黄素-T呈阳性，高锰酸钾氧化后刚果红染色消失。对其中4只猫进行了临床评估。其中2只猫处于终末期尿毒症，伴有非再生性贫血、氮质血症、高磷血症、代谢性酸中毒、轻度高血糖、等渗尿、蛋白尿、管型尿和轻度血尿。其余2只猫仅为中度氮质血症。3只猫患有严重牙龈炎，所有4只猫因球蛋白血症而出现高蛋白血症。
