Cancer Genetics, Stanford Health Care and Department of Pediatrics (Genetics), Stanford University School of Medicine, Palo Alto, CA, USA.
Center for Cancer Risk Assessment, Massachusetts General Hospital, Boston, MA, USA.
Fam Cancer. 2023 Oct;22(4):437-448. doi: 10.1007/s10689-023-00341-4. Epub 2023 Jun 21.
Transgender and gender diverse (TGD) populations with hereditary cancer syndromes face unique obstacles to identifying and obtaining appropriate cancer surveillance and risk-reducing procedures. There is a lack of care provider knowledge about TGD health management. Lynch syndrome (LS) is one of the most common hereditary cancer syndromes, affecting an estimated 1 in 279 individuals. There are no clinical guidelines specific for TGD individuals with LS, highlighting a need to improve the quality of care for this population. There is an urgent need for cancer surveillance recommendations for TGD patients. This commentary provides recommendations for cancer surveillance, risk-reducing strategies, and genetic counseling considerations for TGD patients with LS.
患有遗传性癌症综合征的跨性别和性别多样化（TGD）人群在识别和获得适当的癌症监测和降低风险程序方面面临独特的障碍。护理提供者对 TGD 健康管理的了解不足。林奇综合征（LS）是最常见的遗传性癌症综合征之一，估计每 279 人中就有 1 人受到影响。目前没有针对 LS 跨性别者的具体临床指南，这突出表明需要提高该人群的护理质量。迫切需要为 TGD 患者制定癌症监测建议。本评论提供了针对 LS 跨性别患者的癌症监测、降低风险策略和遗传咨询注意事项的建议。
