Ophthalmology Department, Shamir (Assaf-Harofeh) Medical Center, 70300, Zerifin, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Graefes Arch Clin Exp Ophthalmol. 2023 Dec;261(12):3503-3510. doi: 10.1007/s00417-023-06110-4. Epub 2023 Jun 21.
To assess the influence of iris color on the predisposition for intraoperative floppy iris syndrome (IFIS) during cataract surgery.
Medical records of patients who underwent cataract surgery in two medical centers between July 2019 and February 2020 were reviewed. Patients younger than 50 years, with preexisting ocular conditions affecting pupillary size or anterior chamber depth (ACD), and combined procedures were excluded. The remaining patients were questioned via telephone regarding their iris color. The association of IFIS occurrence and severity with iris color was tested using univariant and multivariant analyses.
Overall, 155 eyes of 155 patients were included, 74 with documented IFIS and 81 without. The mean age was 74.03 ± 7.09 years, and 35.5% were female. The most common iris color among study eyes was brown (110/155, 70.97%), followed by blue (25/155, 16.13%) and green (20/155, 12.90%). Compared to brown-colored eyes, blue irises exhibited a 4.50-fold risk for IFIS (OR = 4.50, 95% CI: 1.73-11.70, p = 0.002), and green irises 7.00-fold risk (OR = 7.00, 95% CI: 2.19-22.39, p = 0.001). After adjusting for possible confounders, the results remained statistically significant (p < 0.01). Light-colored irises tended to exhibit a more severe IFIS compared to the brown iris group (p < 0.001). IFIS bilaterality was also affected by iris color (p < 0.001), with a 10.43-fold risk for fellow eye IFIS in the green iris group compared to eyes with brown irises (OR = 10.43, 95% CI: 3.35-32.54, p < 0.001).
Light iris color was associated with a significantly increased risk of IFIS occurrence, severity, and bilaterality on univariate and multivariate analysis in this study.
评估虹膜颜色对白内障手术中术中虹膜松软综合征（IFIS）易感性的影响。
回顾了 2019 年 7 月至 2020 年 2 月期间在两个医疗中心接受白内障手术的患者的病历。排除年龄小于 50 岁、存在影响瞳孔大小或前房深度（ACD）的预先存在的眼部疾病以及联合手术的患者。通过电话询问其余患者的虹膜颜色。使用单变量和多变量分析测试 IFIS 发生和严重程度与虹膜颜色之间的关联。
共有 155 名患者的 155 只眼纳入研究，其中 74 只眼有记录的 IFIS，81 只眼没有。平均年龄为 74.03±7.09 岁，35.5%为女性。研究眼中最常见的虹膜颜色是棕色（110/155，70.97%），其次是蓝色（25/155，16.13%）和绿色（20/155，12.90%）。与棕色眼睛相比，蓝色虹膜发生 IFIS 的风险高 4.50 倍（OR=4.50，95%CI：1.73-11.70，p=0.002），绿色虹膜发生 IFIS 的风险高 7.00 倍（OR=7.00，95%CI：2.19-22.39，p=0.001）。在调整可能的混杂因素后，结果仍具有统计学意义（p<0.01）。浅色虹膜与棕色虹膜组相比，IFIS 往往更严重（p<0.001）。IFIS 的双侧性也受虹膜颜色的影响（p<0.001），与棕色虹膜相比，绿色虹膜组的对侧眼 IFIS 风险高 10.43 倍（OR=10.43，95%CI：3.35-32.54，p<0.001）。
在本研究中，单变量和多变量分析均显示，虹膜颜色浅与 IFIS 的发生、严重程度和双侧性显著相关。
