验证泰国队列中早产儿视网膜病变（ROP）筛查标准的出生后生长（G-ROP）。
Validation of the postnatal growth and retinopathy of prematurity (G-ROP) screening criteria in a Thai cohort.
机构信息
Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Division of Neonatology, Department of Paediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
出版信息
Jpn J Ophthalmol. 2023 Jul;67(4):387-395. doi: 10.1007/s10384-023-01003-9. Epub 2023 Jun 21.
PURPOSE
To validate Postnatal Growth and Retinopathy of Prematurity (G-ROP) criteria for Thai infants.
STUDY DESIGN
A retrospective review of infants receiving ROP screening during 2009-2020.
METHODS
Baseline characteristics, clinical progression and final ROP outcomes were collected. G-ROP was applied to infants who met at least one of the following 6 criteria: birth weight (BW) below 1051 g, gestational age (GA) under 28 weeks, weight gain (WG) less than 120 g during postnatal day 10-19, WG less than 180 g during day 20-29, WG less than 170 g during day 30-39 and hydrocephalus.
RESULTS
A total of 684 infants (boys, 53.4%) were included. Median (IQR) BW was 1200 (960-1470) grams and median GA was 30 (28-32) weeks. Prevalence of ROP was 26.6%, with 28 (4.1%) having type 1, 19 (2.8%) type 2 and, 135 (19.7%) having other ROP. Treatment was performed in 26 infants (3.8%). Sensitivity of G-ROP to include type 1, 2 or treatment-requiring ROP cases was 100% with 36.9% specificity, excluding 235 (34.4%) cases of unnecessary screening. To adjust for our setting of initial eye examination at 4 weeks' postnatal date, the last 2 criteria of G-ROP were replaced by the occurrence of grade 3 or 4 intraventricular hemorrhage (IVH). This modified G-ROP criteria yielded 100% sensitivity, 42.5% specificity and excluded 271 (39.6%) cases of unnecessary screening.
CONCLUSION
G-ROP criteria can be applied to our hospital setting. Occurrence of IVH grade 3 or 4 was proposed as an alternative in modified G-ROP criteria.
目的
验证泰国婴儿的产后生长与早产儿视网膜病变（ROP）（G-ROP）标准。
研究设计
对 2009 年至 2020 年期间接受 ROP 筛查的婴儿进行回顾性研究。
方法
收集基线特征、临床进展和最终 ROP 结果。将符合以下 6 项标准之一的婴儿应用 G-ROP：出生体重（BW）低于 1051g、胎龄（GA）低于 28 周、出生后第 10-19 天体重增加（WG）小于 120g、第 20-29 天 WG 小于 180g、第 30-39 天 WG 小于 170g 和脑积水。
结果
共纳入 684 名婴儿（男婴占 53.4%）。BW 的中位数（IQR）为 1200（960-1470）g，GA 的中位数为 30（28-32）周。ROP 的患病率为 26.6%，其中 28 例（4.1%）为 1 型，19 例（2.8%）为 2 型，135 例（19.7%）为其他 ROP。26 例（3.8%）婴儿接受了治疗。G-ROP 对包括 1 型、2 型或治疗需要 ROP 病例的敏感性为 100%，特异性为 36.9%，排除了 235 例（34.4%）不必要的筛查。为了调整我们在出生后 4 周进行初次眼部检查的设置，G-ROP 的后两个标准被脑室出血（IVH）3 级或 4 级的发生所取代。修改后的 G-ROP 标准具有 100%的敏感性、42.5%的特异性，排除了 271 例（39.6%）不必要的筛查。
结论
G-ROP 标准可应用于我院。提出 IVH 3 级或 4 级作为修改后 G-ROP 标准的替代。
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