Duan Yuanqiong, Zhang Peixuan, Zhang Tianyue, Zhou Lu, Yin Rutie
Department of Obstetrics and Gynecology, West China Second Hospital of Sichuan University, Chengdu, Sichuan, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China.
Front Oncol. 2023 Jun 5;13:1151871. doi: 10.3389/fonc.2023.1151871. eCollection 2023.
In the last decades, growing attention has been focused on identifying effective therapeutic strategies in the orphan clinical setting of women with platinum-resistant ovarian cancer (PROC), generating thousands of original articles. However, the literature involving bibliometric analysis of PROC has not been published yet.
This study hopes to gain a better understanding of the hot spots and trends in PROC by conducting a bibliometric analysis, as well as identify potential new research directions.
We searched the Web of Science Core Collection (WOSCC) for PROC-related articles published between 1990 and 2022. CiteSpace 6.1.R2 and VOS viewer 1.6.18.0 were primarily utilized to evaluate the contribution and co-occurrence relationships of various countries and regions, institutes, and journals and to identify research hotspots and promising future trends in this research field.
A total of 3,462 Web of Science publications were retrieved that were published in 671 academic journals by 1135 authors from 844 organizations in 75 countries and regions. The United States was the leading contributor in this field, and the University of Texas MD Anderson Cancer Center was the most productive institution. Gynecologic Oncology was the most productive journal, while the Journal of Clinical Oncology was the most cited and influential. Co-citation cluster labels revealed the characteristics of seven major clusters, including synthetic lethality, salvage treatment, human ovarian-carcinoma cell line, PARP inhibitor resistance, antitumor complexes, folate receptor, and targeting platinum-resistant disease. Keywords and references burst detection indicated that biomarkers, genetic and phenotypic changes, immunotherapy, and targeted therapy were the most recent and most significant aspects of PROC research.
This study conducted a comprehensive review of PROC research using bibliometric and visual techniques. Understanding the immunological landscape of PROC and identifying the population that can benefit from immunotherapy, especially in combination with other therapeutic options (such as chemotherapy and targeted therapy), will continue to be the focal point of research.
在过去几十年中，越来越多的注意力集中在为铂耐药卵巢癌（PROC）这一罕见临床病例寻找有效的治疗策略上，由此产生了数千篇原创文章。然而，涉及PROC文献计量分析的文献尚未发表。
本研究希望通过文献计量分析更好地了解PROC的研究热点和趋势，并确定潜在的新研究方向。
我们在科学网核心合集（WOSCC）中检索了1990年至2022年间发表的与PROC相关的文章。主要利用CiteSpace 6.1.R2和VOS viewer 1.6.18.0评估各个国家和地区、机构及期刊的贡献和共现关系，并确定该研究领域的研究热点和未来有前景的趋势。
共检索到3462篇科学网出版物，这些文章由来自75个国家和地区844个组织的1135位作者发表在671种学术期刊上。美国是该领域的主要贡献者，德克萨斯大学MD安德森癌症中心是产出最多的机构。《妇科肿瘤学》是产出最多的期刊，而《临床肿瘤学杂志》是被引用次数最多且最具影响力的期刊。共被引聚类标签揭示了七个主要聚类的特征，包括合成致死、挽救治疗、人卵巢癌细胞系、PARP抑制剂耐药、抗肿瘤复合物、叶酸受体和靶向铂耐药疾病。关键词和参考文献爆发检测表明，生物标志物、基因和表型变化、免疫疗法和靶向疗法是PROC研究中最新且最重要的方面。
本研究使用文献计量和可视化技术对PROC研究进行了全面综述。了解PROC的免疫格局并确定可从免疫疗法中获益的人群，尤其是与其他治疗方案（如化疗和靶向疗法）联合使用时，仍将是研究的重点。
