School of Public Health, Guangxi Medical University, Nanning, China.
Guangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, China.
Front Cell Infect Microbiol. 2023 Jun 5;13:1119875. doi: 10.3389/fcimb.2023.1119875. eCollection 2023.
Gut microbiota is the largest population of microorganisms and is closely related to health. Many studies have explored changes in gut microbiota in viral hepatitis. However, the correlation between gut microbiota and the occurrence and progression of viral hepatitis has not been fully clarified.
PubMed and BioProject databases were searched for studies about viral hepatitis disease and 16S rRNA gene sequencing of gut microbiota up to January 2023. With bioinformatics analyses, we explored changes in microbial diversity of viral hepatitis, screened out crucial bacteria and microbial functions related to viral hepatitis, and identified the potential microbial markers for predicting risks for the occurrence and progression of viral hepatitis based on ROC analysis.
Of the 1389 records identified, 13 studies met the inclusion criteria, with 950 individuals including 656 patient samples (HBV, = 546; HCV, = 86; HEV, = 24) and 294 healthy controls. Gut microbial diversity is significantly decreased as the infection and progression of viral hepatitis. Alpha diversity and microbiota including , , , and were identified as the potential microbial markers for predicting the risk of development of viral hepatitis (AUC>0.7). Microbial functions including tryptophan metabolism, fatty acid biosynthesis, lipopolysaccharide biosynthesis, and lipid metabolism related to the microbial community increased significantly as the development of viral hepatitis.
This study demonstrated comprehensively the gut microbiota characteristics in viral hepatitis, screened out crucial microbial functions related to viral hepatitis, and identified the potential microbial markers for predicting the risk of viral hepatitis.
肠道微生物群是最大的微生物种群，与健康密切相关。许多研究探索了病毒性肝炎中肠道微生物群的变化。然而，肠道微生物群与病毒性肝炎的发生和进展之间的相关性尚未完全阐明。
检索了PubMed 和 BioProject 数据库中关于病毒性肝炎疾病和肠道微生物群 16S rRNA 基因测序的研究，截至 2023 年 1 月。通过生物信息学分析，我们探讨了病毒性肝炎中微生物多样性的变化，筛选出与病毒性肝炎相关的关键细菌和微生物功能，并基于 ROC 分析确定了预测病毒性肝炎发生和进展风险的潜在微生物标志物。
在确定的 1389 条记录中，有 13 项研究符合纳入标准，共纳入 950 人，包括 656 例患者样本（HBV，n=546；HCV，n=86；HEV，n=24）和 294 名健康对照。肠道微生物多样性随着病毒性肝炎的感染和进展而显著降低。α多样性和包括、、、和在内的微生物群被确定为预测病毒性肝炎发展风险的潜在微生物标志物（AUC>0.7）。与微生物群落相关的微生物功能，包括色氨酸代谢、脂肪酸生物合成、脂多糖生物合成和脂质代谢，随着病毒性肝炎的发展而显著增加。
本研究全面展示了病毒性肝炎中的肠道微生物群特征，筛选出与病毒性肝炎相关的关键微生物功能，并确定了预测病毒性肝炎风险的潜在微生物标志物。
