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使用异金属镁钛金属有机催化剂合成的用于弹性体聚合物网络的可注射和可光固化大分子单体。

Injectable and photocurable macromonomers synthesized using a heterometallic magnesium-titanium metal-organic catalyst for elastomeric polymer networks.

作者信息

Niedźwiedź Malwina J, Ignaczak Wojciech, Sobolewski Peter, Goszczyńska Agata, Demirci Gokhan, El Fray Miroslawa

机构信息

Department of Polymer and Biomaterials Science, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin Al. Piastów 45 70-311 Szczecin Poland

出版信息

RSC Adv. 2023 Jun 19;13(27):18371-18381. doi: 10.1039/d3ra02157b. eCollection 2023 Jun 15.

DOI:10.1039/d3ra02157b
PMID:37342811
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10277904/
Abstract

Injectable and photocurable biomaterials are receiving a lot of attention due to their ease of application syringe or dedicated applicator and ability to be used in laparoscopic and robotic minimally invasive procedures. The aim of this work was to synthesize photocurable ester-urethane macromonomers using a heterometallic magnesium-titanium catalyst, magnesium-titanium(iv) butoxide for elastomeric polymer networks. The progress of the two-step synthesis of macromonomers was monitored using infrared spectroscopy. The chemical structure and molecular weight of the obtained macromonomers were characterized using nuclear magnetic resonance spectroscopy and gel permeation chromatography. The dynamic viscosity of the obtained macromonomers was evaluated by a rheometer. Next, the photocuring process was studied under both air and argon atmospheres. Both the thermal and dynamic mechanical thermal properties of the photocured soft and elastomeric networks were investigated. Finally, cytotoxicity screening of polymer networks based on ISO10993-5 revealed high cell viability (over 77%) regardless of curing atmosphere. Overall, our results indicate that this heterometallic magnesium-titanium butoxide catalyst can be an attractive alternative to commonly used homometallic catalysts for the synthesis of injectable and photocurable materials for medical applications.

摘要

可注射且可光固化的生物材料因其可通过注射器或专用涂抹器轻松应用，以及能够用于腹腔镜和机器人辅助的微创手术而备受关注。本研究的目的是使用异金属镁钛催化剂丁氧基镁钛（IV）合成用于弹性体聚合物网络的可光固化酯 - 聚氨酯大分子单体。使用红外光谱监测大分子单体两步合成的进展。使用核磁共振光谱和凝胶渗透色谱对所得大分子单体的化学结构和分子量进行表征。通过流变仪评估所得大分子单体的动态粘度。接下来，研究了在空气和氩气气氛下的光固化过程。研究了光固化的柔软弹性体网络的热性能和动态机械热性能。最后，基于ISO10993 - 5对聚合物网络进行细胞毒性筛选，结果表明无论固化气氛如何，细胞活力都很高（超过77%）。总体而言，我们的结果表明，这种异金属丁氧基镁钛催化剂对于合成用于医疗应用的可注射且可光固化材料而言，可能是常用同金属催化剂的一个有吸引力的替代方案。

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