Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Sci Transl Med. 2014 Jan 8;6(218):218ra6. doi: 10.1126/scitranslmed.3006557.
Currently, there are no clinically approved surgical glues that are nontoxic, bind strongly to tissue, and work well within wet and highly dynamic environments within the body. This is especially relevant to minimally invasive surgery that is increasingly performed to reduce postoperative complications, recovery times, and patient discomfort. We describe the engineering of a bioinspired elastic and biocompatible hydrophobic light-activated adhesive (HLAA) that achieves a strong level of adhesion to wet tissue and is not compromised by preexposure to blood. The HLAA provided an on-demand hemostatic seal, within seconds of light application, when applied to high-pressure large blood vessels and cardiac wall defects in pigs. HLAA-coated patches attached to the interventricular septum in a beating porcine heart and resisted supraphysiologic pressures by remaining attached for 24 hours, which is relevant to intracardiac interventions in humans. The HLAA could be used for many cardiovascular and surgical applications, with immediate application in repair of vascular defects and surgical hemostasis.
目前，还没有临床认可的无毒、能与组织牢固结合、且能在体内潮湿和高度动态环境中发挥良好作用的外科胶水。这对于微创外科尤为重要，微创外科越来越多地用于减少术后并发症、恢复时间和患者不适。我们描述了一种仿生弹性和生物相容性的疏水性光激活粘合剂（HLAA）的工程设计，它可以在湿组织上实现高强度的粘附，并且不会因预先暴露于血液而受到影响。HLAA 可以在数秒内按需提供止血密封，当应用于猪的大血管和心脏壁缺陷时，压力很高。HLAA 涂层的补片贴在跳动的猪心的室间隔上，并能抵抗超过生理压力 24 小时，这与人类的心脏内介入治疗有关。HLAA 可用于许多心血管和外科应用，可立即用于修复血管缺陷和外科止血。
