Department of Biotechnology, Bengbu Medical College, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Anhui 233030, China.
Department of Biochemistry and Molecular Biology, Bengbu Medical College, Anhui 233030, China.
Biomed Pharmacother. 2023 Sep;165:115009. doi: 10.1016/j.biopha.2023.115009. Epub 2023 Jun 19.
Tumor cells are able to use glycolysis to produce energy under hypoxic conditions, and even under aerobic conditions, they rely mainly on glycolysis for energy production, the Warburg effect. Conventional tumor therapeutic drugs are unidirectional, lacking in targeting and have limited therapeutic effect. The development of a large number of nanocarriers and targeted glycolysis for the treatment of tumors has been extensively investigated in order to improve the therapeutic efficacy. This paper reviews the research progress of nanocarriers based on targeting key glycolytic enzymes and related transporters, and combines nanocarrier systems with other therapeutic approaches to provide a new strategy for targeted glycolytic treatment of tumors, providing a theoretical reference for achieving efficient targeted treatment of tumors.
肿瘤细胞能够在缺氧条件下利用糖酵解产生能量，即使在有氧条件下，它们也主要依赖糖酵解来产生能量，即瓦博格效应。传统的肿瘤治疗药物具有单向性、靶向性差、治疗效果有限等缺点。为了提高治疗效果，人们广泛研究了大量的纳米载体和靶向糖酵解治疗肿瘤的方法。本文综述了基于靶向关键糖酵解酶和相关转运体的纳米载体的研究进展，并将纳米载体系统与其他治疗方法相结合，为肿瘤的靶向糖酵解治疗提供了新的策略，为实现高效的肿瘤靶向治疗提供了理论参考。
