针对神经退行性疾病中的 Gasdermin E。
Targeting gasdermin E in neurodegenerative diseases.
机构信息
National Neuroscience Institute of Singapore, 11 Jalan Tan Tock Seng, Singapore, 30843, Singapore; Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.
National Neuroscience Institute of Singapore, 11 Jalan Tan Tock Seng, Singapore, 30843, Singapore.
出版信息
Cell Rep Med. 2023 Jun 20;4(6):101075. doi: 10.1016/j.xcrm.2023.101075.
Abstract
Neel et al. identified pathophysiologic clues linking gasdermin-E (GSDME) with frontotemporal dementia and amyotrophic lateral sclerosis. Therapeutic studies targeting GSDME may provide a viable approach for neurodegenerative diseases.
摘要
尼尔等人发现了 gasdermin-E (GSDME) 与额颞叶痴呆和肌萎缩性侧索硬化症之间的病理生理联系。针对 GSDME 的治疗研究可能为神经退行性疾病提供一种可行的治疗方法。
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