Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, K1A 0K9, Canada; School of Public Health Sciences, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.
Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, K1A 0K9, Canada.
Environ Res. 2023 Sep 15;233:116463. doi: 10.1016/j.envres.2023.116463. Epub 2023 Jun 19.
Prenatal and childhood mercury (Hg) exposures have been associated with negative impacts on child neurodevelopment. It is unclear if associations persist at the low Hg exposures typical in Western countries.
To examine associations between prenatal/childhood blood Hg concentrations and child IQ in Canadian male and female children while considering the potential modifying role of prenatal fish consumption.
We analyzed data from the Maternal-Infant Research on Environmental Chemicals study. Hg was measured in first trimester (n = 527), cord (n = 430), and child (at 3-4 years of age, n = 355) blood and examined sex-stratified associations between blood Hg and children's Full Scale IQ (FSIQ), Verbal IQ (VIQ), Performance IQ (PIQ), and General Language Composite (GLC) scores (assessed with WPPSI-III). Prenatal Hg analyses were further stratified by prenatal fish consumption (low: 0-2, moderate: 3-7, or high: ≥8 times/month).
Higher cord blood Hg concentrations were associated with lower PIQ (ß = -3.27; 95%CI: 6.44, -0.09) in male children with the lowest prenatal fish consumption. Progressively stronger positive associations were observed with PIQ in male children for moderate (ß = 1.08; 95%CI: 0.10, 2.26) and high (ß = 3.07; 95%CI: 1.95, 4.19) prenatal fish consumption. Cord blood Hg concentrations were positively associated with female children's FSIQ (ß = 1.29; 95% CI: 0.77, 1.81) and PIQ (ß = 2.01; 95% CI: 1.19, 2.83); however, when stratified only in the highest fish consumption subgroup. Among female children, higher child blood Hg concentrations were associated with an approximately 1-point increase in FSIQ, VIQ, and GLC.
Prenatal exposure to low levels of Hg was associated with lower PIQ scores in male children with low prenatal fish intake. Positive associations between cord and child blood Hg concentrations and IQ were primarily observed in female children and may be due to beneficial effects of prenatal fish intake.
产前和儿童时期的汞（Hg）暴露与儿童神经发育的负面影响有关。目前尚不清楚在西方国家典型的低汞暴露水平下，这些关联是否仍然存在。
在考虑产前鱼类摄入潜在调节作用的情况下，研究加拿大男女儿童产前/儿童期血液 Hg 浓度与儿童智商之间的关系。
我们分析了母婴环境化学物质研究的数据。在第一孕期（n=527）、脐带（n=430）和儿童（3-4 岁时，n=355）血液中测量了 Hg，并按性别分层分析了血液 Hg 与儿童全量表智商（FSIQ）、言语智商（VIQ）、操作智商（PIQ）和一般语言综合得分（WPPSI-III 评估）之间的关系。产前 Hg 分析进一步按产前鱼类摄入（低：0-2 次/月，中：3-7 次/月，高：≥8 次/月）进行分层。
脐带血 Hg 浓度与男性儿童最低产前鱼类摄入组的 PIQ 呈负相关（ß=-3.27；95%CI：6.44，-0.09）。在男性儿童中，随着产前鱼类摄入适度（ß=1.08；95%CI：0.10，2.26）和高（ß=3.07；95%CI：1.95，4.19），PIQ 与 PIQ 之间的正相关关系逐渐增强。脐带血 Hg 浓度与女性儿童的 FSIQ（ß=1.29；95%CI：0.77，1.81）和 PIQ（ß=2.01；95%CI：1.19，2.83）呈正相关；然而，当仅在最高鱼类摄入亚组中分层时，情况则相反。在女性儿童中，较高的儿童血液 Hg 浓度与 FSIQ、VIQ 和 GLC 大约增加 1 分有关。
在产前鱼类摄入较低的男性儿童中，产前低水平的 Hg 暴露与较低的 PIQ 评分有关。脐带和儿童血液 Hg 浓度与智商之间的正相关关系主要见于女性儿童，这可能是由于产前鱼类摄入的有益影响。
